Dynamic Arterial Elastance During Experimental Endotoxic Septic Shock: A Potential Marker of Cardiovascular Efficiency
No Thumbnail Available
Identifiers
Date
2020-10-02
Authors
Monge Garcia, Manuel Ignacio
Guijo Gonzalez, Pedro
Saludes Orduna, Paula
Gracia Romero, Manuel
Gil Cano, Anselmo
Messina, Antonio
Rhodes, Andrew
Cecconi, Maurizio
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers media sa
Metrics
Export
Abstract
Dynamic arterial elastance (Ea(dyn)), the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a dynamic parameter relating pressure and flow. We aimed to determine the effects of endotoxic septic shock and hemodynamic resuscitation on Ea(dyn)in an experimental study in 18 New Zealand rabbits. Animals received placebo (SHAM,n= 6) or intravenous lipopolysaccharide (E. Coli 055:B5, 1 mg.kg(-1)) with or without (EDX-R,n= 6; EDX,n= 6) hemodynamic resuscitation (fluid bolus of 20 ml.kg(-1) and norepinephrine for restoring mean arterial pressure). Continuous arterial pressure and aortic blood flow measurements were obtained simultaneously. Cardiovascular efficiency was evaluated by the oscillatory power fraction [%Osc: oscillatory work/left ventricular (LV) total work] and the energy efficiency ratio (EER = LV total work/cardiac output). Ea(dyn)increased in septic animals (from 0.73 to 1.70;p= 0.012) and dropped after hemodynamic resuscitation. Ea(dyn)was related with the %Osc and EER [estimates: -0.101 (-0.137 to -0.064) and -9.494 (-11.964 to -7.024);p
Description
MeSH Terms
DeCS Terms
CIE Terms
Keywords
cardiac output, arterial pressure, septic shock, dynamic arterial elastance, stroke volume variation, pulse pressure variation, Stroke volume, Load, Heart, Algorithms, Impedance, Power