RT Journal Article
T1 Dynamic Arterial Elastance During Experimental Endotoxic Septic Shock: A Potential Marker of Cardiovascular Efficiency
A1 Monge Garcia, Manuel Ignacio
A1 Guijo Gonzalez, Pedro
A1 Saludes Orduna, Paula
A1 Gracia Romero, Manuel
A1 Gil Cano, Anselmo
A1 Messina, Antonio
A1 Rhodes, Andrew
A1 Cecconi, Maurizio
K1 cardiac output
K1 arterial pressure
K1 septic shock
K1 dynamic arterial elastance
K1 stroke volume variation
K1 pulse pressure variation
K1 Stroke volume
K1 Load
K1 Heart
K1 Algorithms
K1 Impedance
K1 Power
AB Dynamic arterial elastance (Ea(dyn)), the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has been suggested as a dynamic parameter relating pressure and flow. We aimed to determine the effects of endotoxic septic shock and hemodynamic resuscitation on Ea(dyn)in an experimental study in 18 New Zealand rabbits. Animals received placebo (SHAM,n= 6) or intravenous lipopolysaccharide (E. Coli 055:B5, 1 mg.kg(-1)) with or without (EDX-R,n= 6; EDX,n= 6) hemodynamic resuscitation (fluid bolus of 20 ml.kg(-1) and norepinephrine for restoring mean arterial pressure). Continuous arterial pressure and aortic blood flow measurements were obtained simultaneously. Cardiovascular efficiency was evaluated by the oscillatory power fraction [%Osc: oscillatory work/left ventricular (LV) total work] and the energy efficiency ratio (EER = LV total work/cardiac output). Ea(dyn)increased in septic animals (from 0.73 to 1.70;p= 0.012) and dropped after hemodynamic resuscitation. Ea(dyn)was related with the %Osc and EER [estimates: -0.101 (-0.137 to -0.064) and -9.494 (-11.964 to -7.024);p
PB Frontiers media sa
YR 2020
FD 2020-10-02
LK https://hdl.handle.net/10668/25061
UL https://hdl.handle.net/10668/25061
LA en
DS RISalud
RD Apr 5, 2025