Trajectories of alcohol consumption during life and the risk of developing breast cancer.

dc.contributor.authorDonat-Vargas, Carolina
dc.contributor.authorGuerrero-Zotano, Ángel
dc.contributor.authorCasas, Ana
dc.contributor.authorBaena-Cañada, José Manuel
dc.contributor.authorLope, Virginia
dc.contributor.authorAntolín, Silvia
dc.contributor.authorGarcia-Saénz, José Ángel
dc.contributor.authorBermejo, Begoña
dc.contributor.authorMuñoz, Montserrat
dc.contributor.authorRamos, Manuel
dc.contributor.authorde Juan, Ana
dc.contributor.authorJara Sánchez, Carlos
dc.contributor.authorSánchez-Rovira, Pedro
dc.contributor.authorAntón, Antonio
dc.contributor.authorBrunet, Joan
dc.contributor.authorGavilá, Joaquín
dc.contributor.authorSalvador, Javier
dc.contributor.authorArriola Arellano, Esperanza
dc.contributor.authorBezares, Susana
dc.contributor.authorFernández de Larrea-Baz, Nerea
dc.contributor.authorPérez-Gómez, Beatriz
dc.contributor.authorMartín, Miguel
dc.contributor.authorPollán, Marina
dc.contributor.funderFundación Científica Asociación Española Contra el Cancer
dc.contributor.funderSociedad Española de Oncología Médica
dc.contributor.funderScholarship ‘Contrato de atracción de talento’ from Community of Madrid
dc.contributor.funderFundación Cerveza y Salud 2005
dc.contributor.funderFederación de Asociaciones de Mujeres con Cáncer de Mama
dc.contributor.groupGEICAM Spanish Breast Cancer Research Group
dc.date.accessioned2025-01-07T13:10:15Z
dc.date.available2025-01-07T13:10:15Z
dc.date.issued2021-09-06
dc.description.abstractWhether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.
dc.description.sponsorshipThis study was funded by the Fundación Científica Asociación Española Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association against Cancer 2006 & 2016) (Marina Pollán), Sociedad Española de Oncología Médica (SEOM) (Spanish Society of Medical Oncology) (Miguel Martín), Scholarship ‘Contrato de atracción de talento’ from Community of Madrid (Carolina Donat-Vargas), Fundación Cerveza y Salud 2005 (Beer and Health Foundation 2005) (Miguel Martín) and Federación de Asociaciones de Mujeres con Cáncer de Mama (FECMA) (Spanish Federation of Associations of Women with Breast Cancer) (Miguel Martín, Marina Pollán).
dc.description.version
dc.identifier.citationDonat-Vargas C, Guerrero-Zotano Á, Casas A, Baena-Cañada JM, Lope V, Antolín S, et al. Trajectories of alcohol consumption during life and the risk of developing breast cancer. Br J Cancer. 2021;125(8):1168-1176.
dc.identifier.doi10.1038/s41416-021-01492-w
dc.identifier.essn1532-1827
dc.identifier.issn1532-1827
dc.identifier.pmcPMC8505448
dc.identifier.pmid34483338
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8505448/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/s41416-021-01492-w.pdf
dc.identifier.urihttps://hdl.handle.net/10668/25305
dc.issue.number8
dc.journal.titleBritish journal of cancer
dc.journal.titleabbreviationBr J Cancer
dc.language.isoen
dc.organizationSAS - Hospital Universitario Puerta del Mar
dc.organizationSAS - Hospital Universitario Virgen del Rocío
dc.organizationSAS - Hospital Universitario de Jaén
dc.organizationInstituto de Investigación e Innovación Biomédica de Cádiz (INiBICA)
dc.page.number1168-1176
dc.provenanceRealizada la curación de contenido 20/05/2025
dc.publisherNature
dc.pubmedtypeComparative Study
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.publisherversionhttps://www.nature.com/articles/s41416-021-01492-w
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAlcohol
dc.subjectBreast cancer
dc.subjectAdolescence
dc.subjectTrajectories
dc.subjectRisk
dc.subject.decsConsumo de Bebidas Alcohólicas
dc.subject.decsNeoplasias de la Mama
dc.subject.decsRiesgo
dc.subject.decsMujeres
dc.subject.decsAdolescente
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAlcohol Drinking
dc.subject.meshBreast Neoplasms
dc.subject.meshCase-Control Studies
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshPostmenopause
dc.subject.meshPremenopause
dc.subject.meshRisk Factors
dc.subject.meshSpain
dc.subject.meshSurveys and Questionnaires
dc.subject.meshYoung Adult
dc.titleTrajectories of alcohol consumption during life and the risk of developing breast cancer.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number125

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
PMC8505448.pdf
Size:
588.22 KB
Format:
Adobe Portable Document Format