Liquid Biopsy as a Tool for the Characterisation and Early Detection of the Field Cancerization Effect in Patients with Oral Cavity Carcinoma
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2021-10-01
Authors
Perez-Ruiz, Elisabeth
Gutierrez, Vanesa
Munoz, Marta
Oliver, Javier
Sanchez, Marta
Galvez-Carvajal, Laura
Rueda-Dominguez, Antonio
Barragan, Isabel
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Abstract
Oral squamous cell carcinoma (OSCC) constitutes approximately 25% of all head and neck cancer, for which the consumption of tobacco and alcohol are the main associated risk factors. The field cancerization effect of OSCC is one of the main reasons for the poor survival rates associated with this disease. Despite some advances, its ccharacterization and early diagnosis continue to challenge modern oncology, and the goal of improving the prognosis remains to be achieved. Among new early diagnostic tools for OSCC that have been proposed, liquid biopsy appears to be an ideal candidate, as studies have shown that the analysis of blood and saliva provides promising data for the early detection of relapses or second tumours.
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oral cell carcinoma, field cancerization, liquid biopsy, Squamous-cell carcinoma, Locally advanced head, Induction chemotherapy, Acquired-resistance, Tumor, Exosomes, Dna, Plasma, Heterogeneity, Fluorouracil