Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/773
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dc.contributor.authorMurphy, Neil-
dc.contributor.authorNorat, Teresa-
dc.contributor.authorFerrari, Pietro-
dc.contributor.authorJenab, Mazda-
dc.contributor.authorBueno-de-Mesquita, Bas-
dc.contributor.authorSkeie, Guri-
dc.contributor.authorDahm, Christina C-
dc.contributor.authorOvervad, Kim-
dc.contributor.authorOlsen, Anja-
dc.contributor.authorTjønneland, Anne-
dc.contributor.authorClavel-Chapelon, Françoise-
dc.contributor.authorBoutron-Ruault, Marie Christine-
dc.contributor.authorRacine, Antoine-
dc.contributor.authorKaaks, Rudolf-
dc.contributor.authorTeucher, Birgit-
dc.contributor.authorBoeing, Heiner-
dc.contributor.authorBergmann, Manuela M-
dc.contributor.authorTrichopoulou, Antonia-
dc.contributor.authorTrichopoulos, Dimitrios-
dc.contributor.authorLagiou, Pagona-
dc.contributor.authorPalli, Domenico-
dc.contributor.authorPala, Valeria-
dc.contributor.authorPanico, Salvatore-
dc.contributor.authorTumino, Rosario-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorSiersema, Peter-
dc.contributor.authorvan Duijnhoven, Franzel-
dc.contributor.authorPeeters, Petra H M-
dc.contributor.authorHjartaker, Anette-
dc.contributor.authorEngeset, Dagrun-
dc.contributor.authorGonzález, Carlos A-
dc.contributor.authorSánchez, Maria-José-
dc.contributor.authorDorronsoro, Miren-
dc.contributor.authorNavarro, Carmen-
dc.contributor.authorArdanaz, Eva-
dc.contributor.authorQuirós, José R-
dc.contributor.authorSonestedt, Emily-
dc.contributor.authorEricson, Ulrika-
dc.contributor.authorNilsson, Lena-
dc.contributor.authorPalmqvist, Richard-
dc.contributor.authorKhaw, Kay-Tee-
dc.contributor.authorWareham, Nick-
dc.contributor.authorKey, Timothy J-
dc.contributor.authorCrowe, Francesca L-
dc.contributor.authorFedirko, Veronika-
dc.contributor.authorWark, Petra A-
dc.contributor.authorChuang, Shu-Chun-
dc.contributor.authorRiboli, Elio-
dc.date.accessioned2013-02-14T13:35:20Z-
dc.date.available2013-02-14T13:35:20Z-
dc.date.issued2012-06-22-
dc.identifier.citationMurphy N, Norat T, Ferrari P, Jenab M, Bueno-de-Mesquita B, Skeie G, et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS ONE 2012; 7(6):e39361es
dc.identifier.issn1932-6203 (Online)-
dc.identifier.otherPMC3382210-
dc.identifier.urihttp://hdl.handle.net/10668/773-
dc.descriptionPubMed - in process.es
dc.description.abstractBACKGROUND Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. METHODOLOGY/PRINCIPAL FINDINGS After a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79-0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals. CONCLUSIONS/SIGNIFICANCE Our results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.es
dc.description.sponsorshipThe coordination of EPIC is financially supported by the European Commission (DG-SANCO); and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer; Institut Gustave Roussy; Mutuelle Générale de l’Education Nationale; and Institut National de la Santé et de la Recherche Médicale (INSERM) (France); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum; and Federal Ministry of Education and Research (Germany); Hellenic Health Foundation; Stavros Niarchos Foundation; and the Hellenic Ministry of Health and Social Solidarity (Greece); Italian Association for Research on Cancer (AIRC); National Research Council; and Associazione Iblea per la Ricerca Epidemiologica (AIRE-ONLUS) Ragusa, Associazione Volontari Italiani Sangu (AVIS) Ragusa, Sicilian Government (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS); Netherlands Cancer Registry (NKR); LK Research Funds; Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); and Statistics Netherlands (the Netherlands); European Research Council (ERC) (grant number ERC-2009-AdG 232997) and Nordforsk; and Nordic Center of Excellence Programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS); Regional Governments of Andalucía, Asturias, Basque Country, Murcia (No. 6236) and Navarra; and the Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública and Instituto de Salud Carlos II (ISCIII RETIC) (RD06/0020) (Spain); Swedish Cancer Society; Swedish Scientific Council; and Regional Government of Skane and Västerbotten (Sweden); Cancer Research UK; Medical Research Council; Stroke Association; British Heart Foundation; Department of Health; Food Standards Agency; and Wellcome Trust (UK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPloS onees
dc.subjectColorectal Neoplasmses
dc.subjectDietary Fiberes
dc.subjectNeoplasias Colorrectaleses
dc.subjectFibras en la Dietaes
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasmses
dc.subject.meshMedical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Fiberes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studieses
dc.titleDietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC).es
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid22761771-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1371/journal.pone.0039361-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039361es
dc.contributor.authoraffiliation[Murphy, N; Norat, T; Vineis, P; Wark, PA;Chuang, SC; Riboli, E] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. [Ferrari, P; Jenab, M; Fedirko, V] International Agency for Research on Cancer (IARC-WHO, Lyon, France. [Bueno-de-Mesquita, B; van Duijnhoven, F] The National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [Bueno-de-Mesquita, B; Siersema, P] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. [Skeie, G; Engeset, D] Institute of Community Medicine, University of Tromsø, Tromsø, Norway. [Dahm, CC] Department of Cardiology, Aarhus University Hospital, Aalborg, Denmark [Dahm, CC; Overvad, K] Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark. [Olsen, A; Tjonneland, A] Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark. [Clavel-Chapelon, F; Boutron-Ruault, MC; Racine, A] Inserm, Centre for Research in Epidemiology and Population Health, U1018, Institut Gustave Roussy, Villejuif, France. [Clavel-Chapelon, F; Boutron-Ruault, MC; Racine, A] Paris South University, UMRS 1018, Villejuif, France. [Kaaks, R; Teucher, B] German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg, Germany. [Boeing, H; Bergmann, MM] Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany. [Trichopoulou, A; Lagiou, P] WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. [Trichopoulou, A] Hellenic Health Foundation, Athens, Greece. [Trichopoulos, D; Lagiou, P] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, Untied States of America. [Trichopoulos, D; Lagiou, P] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [Palli, D] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute–ISPO, Florence, Italy. [Pala, V] Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. [Panico, S] Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. [Tumino, R] Cancer Registry and Histopathology Unit, ‘‘Civile-M.P.Arezzo’’ Hospital, Ragusa, Italy. [Vineis, P] HuGeF Foundation, Torino, Italy. [van Duijnhoven, F] Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. [Peeters, PHM] Julius Centre, University Medical Centre Utrecht, Utrecht, The Netherlands. [Hjartaker, A] Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. [Gonzalez, CA] Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Barcelona, Spain. [Sanchez, MJ] Andalusian School of Public Health, Granada, Spain. [Sanchez, MJ; Navarro, C;Ardanaz, E] CIBER Epidemiology and Public Health CIBERESP, Spain. [Dorronsoro, M] Public Health Division of Gipuzkoa. Basque Regional Health Department and Ciberesp-Biodonostia, San Sebastian, Spain. [Navarro, C] Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain. [Ardanaz, E] Navarre Public Health Institute, Pamplona, Spain. [Quiros, JR] Public Health and Health Planning Directorate, Asturias, Spain. [Sonestedt, E;Ericson, U] Department of Clinical Sciences in Malmö, Lund University, Sweden. [Nilsson, L] Department of Public Health and Clinical Medicine, Medicine, Umea University, Umea, Sweden. [Palmqvis, R] Medical Bioscience, Umea University, Umea, Sweden. [Khaw, K] University of Cambridge, Cambridge, United Kingdom. [Wareham, N] MRC Epidemiology Unit, Cambridge, United Kingdom. [Key, TJ.;Crowe, FL] Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine University of Oxford, Oxford, United Kingdom.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - EASP. Escuela Andaluza de Salud Pública

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