RT Journal Article
T1 Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC).
A1 Murphy, Neil
A1 Norat, Teresa
A1 Ferrari, Pietro
A1 Jenab, Mazda
A1 Bueno-de-Mesquita, Bas
A1 Skeie, Guri
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Olsen, Anja
A1 Tjønneland, Anne
A1 Clavel-Chapelon, Françoise
A1 Boutron-Ruault, Marie Christine
A1 Racine, Antoine
A1 Kaaks, Rudolf
A1 Teucher, Birgit
A1 Boeing, Heiner
A1 Bergmann, Manuela M
A1 Trichopoulou, Antonia
A1 Trichopoulos, Dimitrios
A1 Lagiou, Pagona
A1 Palli, Domenico
A1 Pala, Valeria
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Vineis, Paolo
A1 Siersema, Peter
A1 van Duijnhoven, Franzel
A1 Peeters, Petra H M
A1 Hjartaker, Anette
A1 Engeset, Dagrun
A1 González, Carlos A
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 Navarro, Carmen
A1 Ardanaz, Eva
A1 Quirós, José R
A1 Sonestedt, Emily
A1 Ericson, Ulrika
A1 Nilsson, Lena
A1 Palmqvist, Richard
A1 Khaw, Kay-Tee
A1 Wareham, Nick
A1 Key, Timothy J
A1 Crowe, Francesca L
A1 Fedirko, Veronika
A1 Wark, Petra A
A1 Chuang, Shu-Chun
A1 Riboli, Elio
K1 Colorectal Neoplasms
K1 Dietary Fiber
K1 Neoplasias Colorrectales
K1 Fibras en la Dieta
AB BACKGROUNDEarlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location.METHODOLOGY/PRINCIPAL FINDINGSAfter a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79-0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals.CONCLUSIONS/SIGNIFICANCEOur results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.
PB Public Library of Science
YR 2012
FD 2012-06-22
LK http://hdl.handle.net/10668/773
UL http://hdl.handle.net/10668/773
LA en
NO Murphy N, Norat T, Ferrari P, Jenab M, Bueno-de-Mesquita B, Skeie G, et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS ONE 2012; 7(6):e39361
NO PubMed - in process.
DS RISalud
RD Apr 4, 2025