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Título : Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC).
Autor : Murphy, Neil
Norat, Teresa
Ferrari, Pietro
Jenab, Mazda
Bueno-de-Mesquita, Bas
Skeie, Guri
Dahm, Christina C
Overvad, Kim
Olsen, Anja
Tjønneland, Anne
Clavel-Chapelon, Françoise
Boutron-Ruault, Marie Christine
Racine, Antoine
Kaaks, Rudolf
Teucher, Birgit
Boeing, Heiner
Bergmann, Manuela M
Trichopoulou, Antonia
Trichopoulos, Dimitrios
Lagiou, Pagona
Palli, Domenico
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Vineis, Paolo
Siersema, Peter
van Duijnhoven, Franzel
Peeters, Petra H M
Hjartaker, Anette
Engeset, Dagrun
González, Carlos A
Sánchez, Maria-José
Dorronsoro, Miren
Navarro, Carmen
Ardanaz, Eva
Quirós, José R
Sonestedt, Emily
Ericson, Ulrika
Nilsson, Lena
Palmqvist, Richard
Khaw, Kay-Tee
Wareham, Nick
Key, Timothy J
Crowe, Francesca L
Fedirko, Veronika
Wark, Petra A
Chuang, Shu-Chun
Riboli, Elio
Filiación: [Murphy, N; Norat, T; Vineis, P; Wark, PA;Chuang, SC; Riboli, E] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. [Ferrari, P; Jenab, M; Fedirko, V] International Agency for Research on Cancer (IARC-WHO, Lyon, France. [Bueno-de-Mesquita, B; van Duijnhoven, F] The National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [Bueno-de-Mesquita, B; Siersema, P] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. [Skeie, G; Engeset, D] Institute of Community Medicine, University of Tromsø, Tromsø, Norway. [Dahm, CC] Department of Cardiology, Aarhus University Hospital, Aalborg, Denmark [Dahm, CC; Overvad, K] Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark. [Olsen, A; Tjonneland, A] Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark. [Clavel-Chapelon, F; Boutron-Ruault, MC; Racine, A] Inserm, Centre for Research in Epidemiology and Population Health, U1018, Institut Gustave Roussy, Villejuif, France. [Clavel-Chapelon, F; Boutron-Ruault, MC; Racine, A] Paris South University, UMRS 1018, Villejuif, France. [Kaaks, R; Teucher, B] German Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg, Germany. [Boeing, H; Bergmann, MM] Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany. [Trichopoulou, A; Lagiou, P] WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. [Trichopoulou, A] Hellenic Health Foundation, Athens, Greece. [Trichopoulos, D; Lagiou, P] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, Untied States of America. [Trichopoulos, D; Lagiou, P] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [Palli, D] Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute–ISPO, Florence, Italy. [Pala, V] Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. [Panico, S] Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy. [Tumino, R] Cancer Registry and Histopathology Unit, ‘‘Civile-M.P.Arezzo’’ Hospital, Ragusa, Italy. [Vineis, P] HuGeF Foundation, Torino, Italy. [van Duijnhoven, F] Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. [Peeters, PHM] Julius Centre, University Medical Centre Utrecht, Utrecht, The Netherlands. [Hjartaker, A] Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. [Gonzalez, CA] Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Barcelona, Spain. [Sanchez, MJ] Andalusian School of Public Health, Granada, Spain. [Sanchez, MJ; Navarro, C;Ardanaz, E] CIBER Epidemiology and Public Health CIBERESP, Spain. [Dorronsoro, M] Public Health Division of Gipuzkoa. Basque Regional Health Department and Ciberesp-Biodonostia, San Sebastian, Spain. [Navarro, C] Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain. [Ardanaz, E] Navarre Public Health Institute, Pamplona, Spain. [Quiros, JR] Public Health and Health Planning Directorate, Asturias, Spain. [Sonestedt, E;Ericson, U] Department of Clinical Sciences in Malmö, Lund University, Sweden. [Nilsson, L] Department of Public Health and Clinical Medicine, Medicine, Umea University, Umea, Sweden. [Palmqvis, R] Medical Bioscience, Umea University, Umea, Sweden. [Khaw, K] University of Cambridge, Cambridge, United Kingdom. [Wareham, N] MRC Epidemiology Unit, Cambridge, United Kingdom. [Key, TJ.;Crowe, FL] Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine University of Oxford, Oxford, United Kingdom.
Palabras clave : Colorectal Neoplasms;Dietary Fiber;Neoplasias Colorrectales;Fibras en la Dieta
MeSH: Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Fiber
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies
Fecha de publicación : 22-jun-2012
Editorial : Public Library of Science
Cita Bibliográfica: Murphy N, Norat T, Ferrari P, Jenab M, Bueno-de-Mesquita B, Skeie G, et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS ONE 2012; 7(6):e39361
Abstract: BACKGROUND Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. METHODOLOGY/PRINCIPAL FINDINGS After a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79-0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals. CONCLUSIONS/SIGNIFICANCE Our results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.
Descripción : PubMed - in process.
URI: http://hdl.handle.net/10668/773
Versión del editor : http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039361
DOI: 10.1371/journal.pone.0039361
ISSN : 1932-6203 (Online)
Aparece en las colecciones: 01- Artículos - EASP. Escuela Andaluza de Salud Pública

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