Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/658
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dc.contributor.authorGarrido-Sánchez, Lourdes-
dc.contributor.authorVendrell, Joan-
dc.contributor.authorFernández-García, Diego-
dc.contributor.authorCeperuelo-Mallafré, María Victoria-
dc.contributor.authorChacón, Matilde R-
dc.contributor.authorOcaña-Wilhelmi, Luis-
dc.contributor.authorAlcaide, Juan-
dc.contributor.authorTinahones Madueño, Francisco José-
dc.contributor.authorGarcía-Fuentes, Eduardo-
dc.date.accessioned2012-11-27T12:25:34Z-
dc.date.available2012-11-27T12:25:34Z-
dc.date.issued2012-02-23-
dc.identifier.citationGarrido-Sánchez L, Vendrell J, Fernández-García D, Ceperuelo-Mallafré V, Chacón MR, Ocaña-Wilhelmi L, et al. De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery. PLoS ONE; 7(2):e31280es
dc.identifier.issn1932-6203 (Online)-
dc.identifier.otherPMC3285616-
dc.identifier.urihttp://hdl.handle.net/10668/658-
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractOBJECTIVE De novo lipogenesis is involved in fatty acid biosynthesis and could be involved in the regulation of the triglyceride storage capacity of adipose tissue. However, the association between lipogenic and lipolytic genes and the evolution of morbidly obese subjects after bariatric surgery remains unknown. In this prospective study we analyze the association between the improvement in the morbidly obese patients as a result of bariatric surgery and the basal expression of lipogenic and lipolytic genes. METHODS We study 23 non diabetic morbidly obese patients who were studied before and 7 months after bariatric surgery. Also, we analyze the relative basal mRNA expression levels of lipogenic and lipolytic genes in epiploic visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT). RESULTS When the basal acetyl-CoA carboxylase 1 (ACC1), acetyl-CoA synthetase 2 (ACSS2) and ATP citrate lyase (ACL) expression in SAT was below percentile-50, there was a greater decrease in weight (P = 0.006, P = 0.034, P = 0.026), body mass index (P = 0.008, P = 0.033, P = 0.034) and hip circumference (P = 0.033, P = 0.021, P = 0.083) after bariatric surgery. In VAT, when the basal ACSS2 expression was below percentile-50, there was a greater decrease in hip circumference (P = 0.006). After adjusting for confounding variables in logistic regression models, only the morbidly obese patients with SAT or VAT ACSS2 expression ≥ P50 before bariatric surgery had a lower percentage hip circumference loss (<P50) after bariatric surgery (SAT: P = 0.039; VAT: P = 0.033). CONCLUSIONS A lower basal ACSS2, ACC1 and ACL expression, genes involved in de novo lipogenesis, is associated with a better evolution of anthropometric variables after bariatric surgery. Thus, the previous state of the pathways involved in fatty acid metabolism may have repercussions on the improvement of these patients.es
dc.description.sponsorshipThis work was supported in part by grants from the Instituto de Salud Carlos III (PS09/01060, PS09/00997, PI08/0733, CP06/00119, JCI-2009-04086 and JCI-2010-06395) and Servicio Andaluz de Salud (PI0255/2007).es
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPloS Onees
dc.subjectaminoglycoside N1-acetyltransferasees
dc.subjectACACB protein, humanes
dc.subjectAcetil CoA Carboxilasaes
dc.subjectAcetiltransferasases
dc.subjectTejido adiposoes
dc.subjectAntropometríaes
dc.subjectCirugía bariátricaes
dc.subjectGrasa Intraabdominales
dc.subjectLipogénesises
dc.subjectlipolisises
dc.subjectARN Mensajeroes
dc.subjectGrasa subcutáneaes
dc.subjectATP Citrato (pro-S)-Liasaes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Ligases::Carbon-Carbon Ligases::Acetyl-CoA Carboxylasees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Acetyltransferaseses
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissuees
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometryes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Bariatric Surgeryes
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Abdominal Fat::Intra-Abdominal Fates
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Lipogenesises
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Lipolysises
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messengeres
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Subcutaneous Fates
dc.subject.meshMedical Subject Headings::Health Care::Health Services Administration::Quality of Health Care::Outcome and Process Assessment (Health Care)::Outcome Assessment (Health Care)::Treatment Outcomees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::ATP Citrate (pro-S)-Lyasees
dc.titleDe novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery.es
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid22384010-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1371/journal.pone.0031280-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0031280es
dc.contributor.authoraffiliation[Garrido-Sánchez,L; Vendrell,J; Chacón,MR] Hospital Universitari Joan XXIII, IISPV, Tarragona, Spain. [Fernández-García,D; Ceperuelo-Mallafré,MV; Tinahones Madueño,FJ] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Ocaña-Wilhelmi,L] Servicio de Cirugía, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Alcaide,J; García-Fuentes,E] Fundación IMABIS, Málaga, Spain.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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