RT Journal Article
T1 De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery.
A1 Garrido-Sánchez, Lourdes
A1 Vendrell, Joan
A1 Fernández-García, Diego
A1 Ceperuelo-Mallafré, María Victoria
A1 Chacón, Matilde R
A1 Ocaña-Wilhelmi, Luis
A1 Alcaide, Juan
A1 Tinahones, Francisco J
A1 García-Fuentes, Eduardo
K1 aminoglycoside N1-acetyltransferase
K1 ACACB protein, human
K1 Acetil CoA Carboxilasa
K1 Acetiltransferasas
K1 Tejido adiposo
K1 Antropometría
K1 Cirugía bariátrica
K1 Grasa Intraabdominal
K1 Lipogénesis
K1 lipolisis
K1 ARN Mensajero
K1 Grasa subcutánea
K1 ATP Citrato (pro-S)-Liasa
AB OBJECTIVEDe novo lipogenesis is involved in fatty acid biosynthesis and could be involved in the regulation of the triglyceride storage capacity of adipose tissue. However, the association between lipogenic and lipolytic genes and the evolution of morbidly obese subjects after bariatric surgery remains unknown. In this prospective study we analyze the association between the improvement in the morbidly obese patients as a result of bariatric surgery and the basal expression of lipogenic and lipolytic genes.METHODSWe study 23 non diabetic morbidly obese patients who were studied before and 7 months after bariatric surgery. Also, we analyze the relative basal mRNA expression levels of lipogenic and lipolytic genes in epiploic visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT).RESULTSWhen the basal acetyl-CoA carboxylase 1 (ACC1), acetyl-CoA synthetase 2 (ACSS2) and ATP citrate lyase (ACL) expression in SAT was below percentile-50, there was a greater decrease in weight (P = 0.006, P = 0.034, P = 0.026), body mass index (P = 0.008, P = 0.033, P = 0.034) and hip circumference (P = 0.033, P = 0.021, P = 0.083) after bariatric surgery. In VAT, when the basal ACSS2 expression was below percentile-50, there was a greater decrease in hip circumference (P = 0.006). After adjusting for confounding variables in logistic regression models, only the morbidly obese patients with SAT or VAT ACSS2 expression ≥ P50 before bariatric surgery had a lower percentage hip circumference loss (<P50) after bariatric surgery (SAT: P = 0.039; VAT: P = 0.033).CONCLUSIONSA lower basal ACSS2, ACC1 and ACL expression, genes involved in de novo lipogenesis, is associated with a better evolution of anthropometric variables after bariatric surgery. Thus, the previous state of the pathways involved in fatty acid metabolism may have repercussions on the improvement of these patients.
PB Public Library of Science
YR 2012
FD 2012-02-23
LK http://hdl.handle.net/10668/658
UL http://hdl.handle.net/10668/658
LA en
NO Garrido-Sánchez L, Vendrell J, Fernández-García D, Ceperuelo-Mallafré V, Chacón MR, Ocaña-Wilhelmi L, et al. De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery. PLoS ONE; 7(2):e31280
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 6, 2025