Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/632
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dc.contributor.authorNúñez, Concepción-
dc.contributor.authorOliver, Javier-
dc.contributor.authorMendoza, Juan L-
dc.contributor.authorGómez-García, María-
dc.contributor.authorTaxonera, Carlos-
dc.contributor.authorGómez, Luis M-
dc.contributor.authorLópez-Nevot, Miguel A-
dc.contributor.authorG de laConcha, Emilio-
dc.contributor.authorUrcelay, Elena-
dc.contributor.authorMartínez, Alfonso-
dc.contributor.authorMartín, Javier-
dc.date.accessioned2012-11-21T10:33:13Z-
dc.date.available2012-11-21T10:33:13Z-
dc.date.issued2007-12-10-
dc.identifier.citationNúñez C, Oliver J, Mendoza JL, Gómez-García M, Taxonera C, Gómez LM et al. CD209 in inflammatory bowel disease: a case-control study in the Spanish population. BMC Med Genet. 2007 Dec 10;8:75.es
dc.identifier.issn1471-2350 (Online)-
dc.identifier.otherPMC2241584-
dc.identifier.urihttp://hdl.handle.net/10668/632-
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractBACKGROUND The etiology of Ulcerative Colitis (UC) and Crohn's Disease (CD), considered together as Inflammatory Bowel Diseases (IBD), involves environmental and genetic factors. Although some genes are already known, the genetics underlying these diseases is complex and new candidates are continuously emerging. The CD209 gene is located in a region linked previously to IBD and a CD209 functional polymorphism (rs4804803) has been associated to other inflammatory conditions. Our aim was to study the potential involvement of this CD209 variant in IBD susceptibility. METHODS We performed a case-control study with 515 CD patients, 497 UC patients and 731 healthy controls, all of them white Spaniards. Samples were typed for the CD209 single nucleotide polymorphism (SNP) rs4804803 by TaqMan technology. Frequency comparisons were performed using chi2 tests. RESULTS No association between CD209 and UC or CD was observed initially. However, stratification of UC patients by HLA-DR3 status, a strong protective allele, showed that carriage of the CD209_G allele could increase susceptibility in the subgroup of HLA-DR3-positive individuals (p = 0.03 OR = 1.77 95% CI 1.04-3.02, vs. controls). CONCLUSION A functional variant in the CD209 gene, rs4804803, does not seem to be influencing Crohn's disease susceptibility. However, it could be involved in the etiology or pathology of Ulcerative Colitis in HLA-DR3-positive individuals but further studies are necessary.es
dc.description.sponsorshipThis work was supported by grants SAF2003-08522 and SAF2006-00398. Concepción Núñez and Alfonso Martínez have a FIS contract (CA06/0163 and CP04/00175, respectively) and Elena Urcelay works for the "Fundación para la Investigación Biomédica-Hospital Clínico San Carlos".es
dc.language.isoenes
dc.publisherBioMed Centrales
dc.relation.ispartofBMC medical geneticses
dc.subjectAdultoes
dc.subjectEstudios de Casos y Controleses
dc.subjectMoléculas de Adhesión Celulares
dc.subjectDistribución de Chi-Cuadradoes
dc.subjectColitis Ulcerosaes
dc.subjectEnfermedad de Crohnes
dc.subjectFemeninoes
dc.subjectFrecuencia de los Geneses
dc.subjectMarcadores Genéticoses
dc.subjectPredisposición Genética a la Enfermedades
dc.subjectGenotipoes
dc.subjectAntígenos HLA-DRes
dc.subjectHumanoses
dc.subjectLectinas Tipo Ces
dc.subjectMasculinoes
dc.subjectMediana Edades
dc.subjectPolimorfismo de Nucleótido Simplees
dc.subjectReceptores de Superficie Celulares
dc.subjectEspañaes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studieses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Cell Adhesion Moleculeses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Statistical Distributions::Chi-Square Distributiones
dc.subject.meshMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn Diseasees
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Gene Frequencyes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Genetic Markerses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Diseasees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotypees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigenses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Lectins::Lectins, C-Typees
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotidees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surfacees
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europe::Spaines
dc.titleCD209 in inflammatory bowel disease: a case-control study in the Spanish populationes
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid18070336-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1186/1471-2350-8-75-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://www.biomedcentral.com/1471-2350/8/75es
dc.contributor.authoraffiliation[Núñez,C; G de la Concha,E; Urcelay,E; Martínez,A] Servicio de Inmunología Clínica, Hospital Clínico San Carlos, Madrid, Spain.[Oliver,J; Gómez,LM; Martín,J] Instituto de Parasitología y Biomedicina, CSIC, Granada, Spain.[Mendoza,JL; Taxonera,C] Unidad de Enfermedad Inflamatoria Intestinal, Hospital Clínico San Carlos, Madrid, Spain. [Gómez-García,M] Unidad de Enfermedad Inflamatoria Intestinal, Hospital Virgen de las Nieves, Granada, Spain. [López-Nevot,MA] Servicio de Inmunología, Hospital Virgen de las Nieves, Granada, Spain.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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