RT Journal Article
T1 CD209 in inflammatory bowel disease: a case-control study in the Spanish population
A1 Núñez, Concepción
A1 Oliver, Javier
A1 Mendoza, Juan L
A1 Gómez-García, María
A1 Taxonera, Carlos
A1 Gómez, Luis M
A1 López-Nevot, Miguel A
A1 G de laConcha, Emilio
A1 Urcelay, Elena
A1 Martínez, Alfonso
A1 Martín, Javier
K1 Adulto
K1 Estudios de Casos y Controles
K1 Moléculas de Adhesión Celular
K1 Distribución de Chi-Cuadrado
K1 Colitis Ulcerosa
K1 Enfermedad de Crohn
K1 Femenino
K1 Frecuencia de los Genes
K1 Marcadores Genéticos
K1 Predisposición Genética a la Enfermedad
K1 Genotipo
K1 Antígenos HLA-DR
K1 Humanos
K1 Lectinas Tipo C
K1 Masculino
K1 Mediana Edad
K1 Polimorfismo de Nucleótido Simple
K1 Receptores de Superficie Celular
K1 España
AB BACKGROUNDThe etiology of Ulcerative Colitis (UC) and Crohn's Disease (CD), considered together as Inflammatory Bowel Diseases (IBD), involves environmental and genetic factors. Although some genes are already known, the genetics underlying these diseases is complex and new candidates are continuously emerging. The CD209 gene is located in a region linked previously to IBD and a CD209 functional polymorphism (rs4804803) has been associated to other inflammatory conditions. Our aim was to study the potential involvement of this CD209 variant in IBD susceptibility.METHODSWe performed a case-control study with 515 CD patients, 497 UC patients and 731 healthy controls, all of them white Spaniards. Samples were typed for the CD209 single nucleotide polymorphism (SNP) rs4804803 by TaqMan technology. Frequency comparisons were performed using chi2 tests.RESULTSNo association between CD209 and UC or CD was observed initially. However, stratification of UC patients by HLA-DR3 status, a strong protective allele, showed that carriage of the CD209_G allele could increase susceptibility in the subgroup of HLA-DR3-positive individuals (p = 0.03 OR = 1.77 95% CI 1.04-3.02, vs. controls).CONCLUSIONA functional variant in the CD209 gene, rs4804803, does not seem to be influencing Crohn's disease susceptibility. However, it could be involved in the etiology or pathology of Ulcerative Colitis in HLA-DR3-positive individuals but further studies are necessary.
PB BioMed Central
YR 2007
FD 2007-12-10
LK http://hdl.handle.net/10668/632
UL http://hdl.handle.net/10668/632
LA en
NO Núñez C, Oliver J, Mendoza JL, Gómez-García M, Taxonera C, Gómez LM et al. CD209 in inflammatory bowel disease: a case-control study in the Spanish population. BMC Med Genet. 2007 Dec 10;8:75.
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 5, 2025