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http://hdl.handle.net/10668/4423
Title: | Clearance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection or Liver Transplantation |
Authors: | Amado, Víctor González-Rubio, Sandra Zamora, Javier Alejandre, Rafael Espejo-Cruz, María Lola Linares, Clara Sánchez-Frías, Marina García-Jurado, Gema Montero, José Luis Ciria, Rubén Rodríguez-Perálvarez, Manuel Ferrín, Gustavo De la Mata, Manuel |
metadata.dc.contributor.authoraffiliation: | [Amado,V; Zamora,J; Alejandre,R; Montero,JL; Rodríguez-Perálvarez,M; De la Mata,M] Department of Hepatology and Liver Transplantation, Reina Sofía University Hospital, Córdoba, Spain. [Amado,V; González-Rubio,S; Zamora,J; Alejandre,R; Espejo-Cruz,ML; Linares,C; García-Jurado,G; Montero,JL; Ciria,R; Rodríguez-Perálvarez,M; Ferrín,G; De la Mata,M] Maimónides Institute of Biomedical Research (IMIBIC), University of Córdoba, Córdoba, Spain. [González-Rubio,S; Linares,C; Montero,JL; Rodríguez-Perálvarez,M; Ferrín,G; De la Mata,M] Centro de Investigación Biomédica en Red de Enfermedades hepáticas y digestivas (CIBERehd), Madrid, Spain. [Sánchez-Frías,M] Pathology Department, Reina Sofía University Hospital, Córdoba, Spain. [Ciria,R] Department of Hepatobiliary Surgery and Liver Transplantation, Reina Sofía University Hospital, Córdoba, Spain. |
Keywords: | Hepatocellular carcinoma;Liver transplantation;Liver cancer;Liquid biopsy;Circulating tumor cell;Tumor recurrence;Carcinoma hepatocelular;Trasplante de hígado;Neoplasias hepáticas;Biopsia líquida;Células neoplásicas circulantes;Recurrencia local de neoplasia |
metadata.dc.subject.mesh: | Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Check Tags::Male Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Neoplasms::Carcinoma, Hepatocellular Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Neoplasms Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Digestive System Surgical Procedures::Liver Transplantation Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Pilot Projects Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Neoplastic Processes::Neoplasm Recurrence, Local Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Metastasis::Neoplastic Cells, Circulating Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies Medical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C::Hepatitis C, Chronic Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Cirrhosis Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Services::Tissue and Organ Procurement |
Issue Date: | 19-May-2021 |
Publisher: | MDPI |
Citation: | Amado V, González-Rubio S, Zamora J, Alejandre R, Espejo-Cruz ML, Linares C, et al. Clearance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection or Liver Transplantation. Cancers. 2021 May 19;13(10):2476 |
Abstract: | Background: In patients with hepatocellular carcinoma (HCC), a complete clearance of circulating tumor cells (CTCs) early after liver transplantation (LT) or surgical resection (LR) could prevent tumor recurrence. Methods: prospective pilot study including patients with HCC who underwent LR or LT from September 2017 to May 2020. Enumeration of CTCs was performed in peripheral blood samples (7 mL) using the Isoflux® system (Fluxion Biosciences) immediately before surgery, at post-operative day 5 and at day 30. A clinically relevant number of CTCs was defined as >30 CTCs/sample. Results: 41 HCC patients were included (mean age 58.7 ± 6.3; 82.9% male). LR was performed in 10 patients (24.4%) and 31 patients (75.6%) underwent LT. The main etiology of liver disease was chronic hepatitis C (31.7%). Patients undergoing LR and LT were similar in terms of preoperative CTC count (p = 0.99), but clearance of CTCs within the first month was more pronounced in the LT group. Clusters of CTCs at baseline were associated with incomplete clearance of CTCs at day 30 (54.2% vs. 11.8%, p = 0.005), which in turn impacted negatively on survival (p = 0.038). Conclusion: Incomplete clearance of CTCs after surgery could be a surrogate marker of HCC aggressiveness. |
URI: | http://hdl.handle.net/10668/4423 |
metadata.dc.relation.publisherversion: | https://www.mdpi.com/2072-6694/13/10/2476/htm |
metadata.dc.identifier.doi: | 10.3390/cancers13102476 |
ISSN: | 2072-6694 (Online) |
Appears in Collections: | 01- Artículos - Hospital Reina Sofía 01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba |
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Amado_ClearanceOf.pdf | Artículo publicado | 991,69 kB | Adobe PDF | View/Open |
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