RT Journal Article
T1 Clearance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection or Liver Transplantation
A1 Amado, Víctor
A1 González-Rubio, Sandra
A1 Zamora, Javier
A1 Alejandre, Rafael
A1 Espejo-Cruz, María Lola
A1 Linares, Clara
A1 Sánchez-Frías, Marina
A1 García-Jurado, Gema
A1 Montero, José Luis
A1 Ciria, Rubén
A1 Rodríguez-Perálvarez, Manuel
A1 Ferrín, Gustavo
A1 De la Mata, Manuel
K1 Hepatocellular carcinoma
K1 Liver transplantation
K1 Liver cancer
K1 Liquid biopsy
K1 Circulating tumor cell
K1 Tumor recurrence
K1 Carcinoma hepatocelular
K1 Trasplante de hígado
K1 Neoplasias hepáticas
K1 Biopsia líquida
K1 Células neoplásicas circulantes
K1 Recurrencia local de neoplasia
AB Background: In patients with hepatocellular carcinoma (HCC), a complete clearance of circulating tumor cells (CTCs) early after liver transplantation (LT) or surgical resection (LR) could prevent tumor recurrence. Methods: prospective pilot study including patients with HCC who underwent LR or LT from September 2017 to May 2020. Enumeration of CTCs was performed in peripheral blood samples (7 mL) using the Isoflux® system (Fluxion Biosciences) immediately before surgery, at post-operative day 5 and at day 30. A clinically relevant number of CTCs was defined as >30 CTCs/sample. Results: 41 HCC patients were included (mean age 58.7 ± 6.3; 82.9% male). LR was performed in 10 patients (24.4%) and 31 patients (75.6%) underwent LT. The main etiology of liver disease was chronic hepatitis C (31.7%). Patients undergoing LR and LT were similar in terms of preoperative CTC count (p = 0.99), but clearance of CTCs within the first month was more pronounced in the LT group. Clusters of CTCs at baseline were associated with incomplete clearance of CTCs at day 30 (54.2% vs. 11.8%, p = 0.005), which in turn impacted negatively on survival (p = 0.038). Conclusion: Incomplete clearance of CTCs after surgery could be a surrogate marker of HCC aggressiveness.
PB MDPI
YR 2021
FD 2021-05-19
LK http://hdl.handle.net/10668/4423
UL http://hdl.handle.net/10668/4423
LA en
NO Amado V, González-Rubio S, Zamora J, Alejandre R, Espejo-Cruz ML, Linares C, et al. Clearance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection or Liver Transplantation. Cancers. 2021 May 19;13(10):2476
DS RISalud
RD Apr 14, 2025