Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/4400
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCarrasco-Hernández, Laura-
dc.contributor.authorQuintana-Gallego, Esther-
dc.contributor.authorCalero, Carmen-
dc.contributor.authorReinoso-Arija, Rocío-
dc.contributor.authorRuiz-Duque, Borja-
dc.contributor.authorLópez-Campos, José Luis-
dc.date.accessioned2022-11-23T13:54:23Z-
dc.date.available2022-11-23T13:54:23Z-
dc.date.issued2021-10-10-
dc.identifier.citationCarrasco-Hernández L, Quintana-Gallego E, Calero C, Reinoso-Arija R, Ruiz-Duque B, López-Campos JL. Dysfunction in the Cystic Fibrosis Transmembrane Regulator in Chronic Obstructive Pulmonary Disease as a Potential Target for Personalised Medicine. Biomedicines. 2021 Oct 10;9(10):1437es_ES
dc.identifier.issn2227-9059 (Online)es_ES
dc.identifier.otherPMC8533244es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4400-
dc.description.abstractIn recent years, numerous pathways were explored in the pathogenesis of COPD in the quest for new potential therapeutic targets for more personalised medical care. In this context, the study of the cystic fibrosis transmembrane conductance regulator (CFTR) began to gain importance, especially since the advent of the new CFTR modulators which had the potential to correct this protein's dysfunction in COPD. The CFTR is an ion transporter that regulates the hydration and viscosity of mucous secretions in the airway. Therefore, its abnormal function favours the accumulation of thicker and more viscous secretions, reduces the periciliary layer and mucociliary clearance, and produces inflammation in the airway, as a consequence of a bronchial infection by both bacteria and viruses. Identifying CFTR dysfunction in the context of COPD pathogenesis is key to fully understanding its role in the complex pathophysiology of COPD and the potential of the different therapeutic approaches proposed to overcome this dysfunction. In particular, the potential of the rehydration of mucus and the role of antioxidants and phosphodiesterase inhibitors should be discussed. Additionally, the modulatory drugs which enhance or restore decreased levels of the protein CFTR were recently described. In particular, two CFTR potentiators, ivacaftor and icenticaftor, were explored in COPD. The present review updated the pathophysiology of the complex role of CFTR in COPD and the therapeutic options which could be explored.es_ES
dc.format.extent13 p.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.relation.ispartofBiomedicineses_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCystic fibrosis transmembrane conductance regulatores_ES
dc.subjectCOPDes_ES
dc.subjectCFTR modulatorses_ES
dc.subjectIvacaftores_ES
dc.subjectIcenticaftores_ES
dc.subjectMucociliary clearancees_ES
dc.subjectMucuses_ES
dc.subjectInflammationes_ES
dc.subjectPhosphodiesterase inhibitorses_ES
dc.subjectRegulador de conductancia de transmembrana de fibrosis quísticaes_ES
dc.subjectEnfermedad pulmonar obstructiva crónicaes_ES
dc.subjectDepuración mucociliares_ES
dc.subjectMocoes_ES
dc.subjectInflamaciónes_ES
dc.subjectInhibidores de fosfodiesterasaes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Chloride Channels::Cystic Fibrosis Transmembrane Conductance Regulatores_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Respiratory System::Mucociliary Clearancees_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidantses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Protein Ses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Physicochemical Phenomena::Viscosityes_ES
dc.subject.meshMedical Subject Headings::Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases, Obstructive::Pulmonary Disease, Chronic Obstructivees_ES
dc.subject.meshMedical Subject Headings::Anatomy::Fluids and Secretions::Bodily Secretions::Mucuses_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Phosphodiesterase Inhibitorses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Fluid Therapyes_ES
dc.subject.meshMedical Subject Headings::Organisms::Bacteriaes_ES
dc.subject.meshMedical Subject Headings::Organisms::Viruseses_ES
dc.titleDysfunction in the Cystic Fibrosis Transmembrane Regulator in Chronic Obstructive Pulmonary Disease as a Potential Target for Personalised Medicinees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.versionYeses_ES
dc.identifier.pmid34680554es_ES
dc.rights.accessRightsAcceso abiertoes_ES
dc.identifier.doi10.3390/biomedicines9101437es_ES
dc.type.versioninfo:eu-repo/semantics/publishedes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2227-9059/9/10/1437/htmes_ES
dc.contributor.authoraffiliation[Carrasco-Hernández,L; Quintana-Gallego,E; Calero,C; Reinoso-Arija,R; Ruiz-Duque,B; López-Campos,JL] Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Sevilla, Spain. [Carrasco-Hernández,L; Quintana-Gallego,E; Calero,C; López-Campos,JL] Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.es_ES
dc.type.subtypeRevisiónes_ES
Appears in Collections:01- Artículos - Hospital Virgen del Rocío
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla

Files in This Item:
File Description SizeFormat 
CarrascoHernandez_DysfunctionIn.pdfRevisión1,17 MBAdobe PDFView/Open


This item is protected by original copyright



This item is licensed under a Creative Commons License Creative Commons