Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/4086
Title: 3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency
Authors: Gracia-Marco, Luis
Gonzalez-Salvatierra, Sheila
Garcia-Martin, Antonia
Ubago-Guisado, Esther
Garcia-Fontana, Beatriz
Gil-Cosano, José Juan
Muñoz-Torres, Manuel
metadata.dc.contributor.authoraffiliation: [Gracia-Marco,L; Ubago-Guisado,E; Gil-Cosano,JJ] PROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain. [Gracia-Marco,L; Ubago-Guisado,E] Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain. [Gonzalez-Salvatierra,S; Garcia-Martin,A; Garcia-Fontana,B; Muñoz-Torres,M] Bone Metabolic Unit, Endocrinology and Nutrition Division, University Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain. [Gonzalez-Salvatierra,S; Muñoz-Torres,M] Department of Medicine, University of Granada, Granada, Spain. [Garcia-Martin,A; Garcia-Fontana,B; Muñoz-Torres,M] CIBERFES, Instituto de Salud Carlos III, Madrid, Spain. [Ubago-Guisado,E] Escuela Andaluza de Salud Pública (EASP), Granada, Spain
Keywords: DXA;Bone modelling and remodelling;Bone QCT/microCT;Acromegaly;Cortical bone;Growth hormone;Osteoporosis;Absorciometría de fotón;Acromegalia;Hueso cortical;Hormona del crecimiento
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Persons::Persons::Age Groups::Adult
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Radiography::Absorptiometry, Photon
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density
Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur::Femur Neck
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies
Medical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases, Endocrine::Acromegaly
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Control Groups
Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur
Medical Subject Headings::Information Science::Information Science::Computing Methodologies::Software
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Growth Hormone
Medical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases, Metabolic::Osteoporosis
Issue Date: 9-Feb-2021
Publisher: MDPI
Citation: Gracia-Marco L, Gonzalez-Salvatierra S, Garcia-Martin A, Ubago-Guisado E, Garcia-Fontana B, Gil-Cosano JJ, et al. 3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency. J Clin Med. 2021 Feb 9;10(4):657.
Abstract: The skeleton is regulated by and responds to pituitary hormones, especially when the circulating levels are perturbed in disease. This study aims to analyse the between-group differences in 3D dual-energy X-ray absorptiometry (DXA) parameters at the hip site among patients with acromegaly or adult growth hormone deficiency (AGHD) and a healthy control group. The current cross-sectional study includes data for 67 adults, 20 with acromegaly, 14 with AGHD and 33 healthy controls. We obtained the areal bone mineral density (aBMD) outcomes using DXA and cortical and trabecular parameters using 3D-DXA software (3D-SHAPER). The mean-adjusted 3D-DXA parameters did not differ between acromegaly patients and the controls (p > 0.05); however, we found cortical bone impairment (-7.3% to -8.4%; effect size (ES) = 0.78) in AGHD patients (p < 0.05). Differences in the cortical bone parameters were more evident when comparing AGHD patients (-8.5% to -16.2%; ES = 1.22 to 1.24) with acromegaly patients (p < 0.05). In brief, the 3D mapping highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and the controls. Overall, AGHD patients displayed lower cortical parameters at the trochanter, femoral neck and intertrochanter compared to the controls and acromegaly patients. To sum up, 3D-DXA provided useful information about the characteristics of bone involvement in growth hormone (GH)-related disorders. Patients with AGHD showed distinct involvement of the cortical structure.
URI: http://hdl.handle.net/10668/4086
metadata.dc.relation.publisherversion: https://www.mdpi.com/2077-0383/10/4/657/htm
metadata.dc.identifier.doi: 10.3390/jcm10040657
ISSN: 2077-0383 (Online)
Appears in Collections:01- Artículos - EASP. Escuela Andaluza de Salud Pública
01- Artículos - Hospital San Cecilio
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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