RT Journal Article
T1 3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency
A1 Gracia-Marco, Luis
A1 Gonzalez-Salvatierra, Sheila
A1 Garcia-Martin, Antonia
A1 Ubago-Guisado, Esther
A1 Garcia-Fontana, Beatriz
A1 Gil-Cosano, José Juan
A1 Muñoz-Torres, Manuel
K1 DXA
K1 Bone modelling and remodelling
K1 Bone QCT/microCT
K1 Acromegaly
K1 Cortical bone
K1 Growth hormone
K1 Osteoporosis
K1 Absorciometría de fotón
K1 Acromegalia
K1 Hueso cortical
K1 Hormona del crecimiento
AB The skeleton is regulated by and responds to pituitary hormones, especially when the circulating levels are perturbed in disease. This study aims to analyse the between-group differences in 3D dual-energy X-ray absorptiometry (DXA) parameters at the hip site among patients with acromegaly or adult growth hormone deficiency (AGHD) and a healthy control group. The current cross-sectional study includes data for 67 adults, 20 with acromegaly, 14 with AGHD and 33 healthy controls. We obtained the areal bone mineral density (aBMD) outcomes using DXA and cortical and trabecular parameters using 3D-DXA software (3D-SHAPER). The mean-adjusted 3D-DXA parameters did not differ between acromegaly patients and the controls (p > 0.05); however, we found cortical bone impairment (-7.3% to -8.4%; effect size (ES) = 0.78) in AGHD patients (p < 0.05). Differences in the cortical bone parameters were more evident when comparing AGHD patients (-8.5% to -16.2%; ES = 1.22 to 1.24) with acromegaly patients (p < 0.05). In brief, the 3D mapping highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and the controls. Overall, AGHD patients displayed lower cortical parameters at the trochanter, femoral neck and intertrochanter compared to the controls and acromegaly patients. To sum up, 3D-DXA provided useful information about the characteristics of bone involvement in growth hormone (GH)-related disorders. Patients with AGHD showed distinct involvement of the cortical structure.
PB MDPI
YR 2021
FD 2021-02-09
LK http://hdl.handle.net/10668/4086
UL http://hdl.handle.net/10668/4086
LA en
NO Gracia-Marco L, Gonzalez-Salvatierra S, Garcia-Martin A, Ubago-Guisado E, Garcia-Fontana B, Gil-Cosano JJ, et al. 3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency. J Clin Med. 2021 Feb 9;10(4):657.
DS RISalud
RD Apr 18, 2025