Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2667
Full metadata record
DC FieldValueLanguage
dc.contributor.authorEstades-Rubio, Francisco J-
dc.contributor.authorReyes-Martín, Alvaro-
dc.contributor.authorMorales-Marcos, Victor-
dc.contributor.authorGarcía-Piriz, Mercedes-
dc.contributor.authorGarcía-Vera, Juan J-
dc.contributor.authorPerán, Macarena-
dc.contributor.authorMarchal, Juan A-
dc.contributor.authorMontañez-Heredia, Elvira-
dc.date.accessioned2017-05-26T10:43:04Z-
dc.date.available2017-05-26T10:43:04Z-
dc.date.issued2017-03-17-
dc.identifier.citationEstades-Rubio FJ, Reyes-Martín A, Morales-Marcos V, García-Piriz M, García-Vera JJ, Perán M, et al.Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid. Int J Mol Sci. 2017; 18(3).es_ES
dc.identifier.issn1422-0067 (Online)es_ES
dc.identifier.otherPMC5372670es_ES
dc.identifier.urihttp://hdl.handle.net/10668/2667-
dc.description.abstractGiven the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II and III) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score greater than 7, with a homogeneous distribution of age, sex, BMI, and duration of disease, were included in this study. Patients were randomized into two groups: Group I was treated with NASHA (Durolane(®)) and Group II with HA (Go-ON(®)). Patient's evolution was followed up at the 1st, 2nd, 4th, 8th, 12th, and 26th week after treatment. A statistically significant improvement in WOMAC score was observed for patients treated with NASHA versus those who received HA at Week 26. In addition, the need for analgesia was significantly reduced at Week 26 in the NASHA-treated group. Finally, the economic analysis showed an increased cost of overall treatment with HA injections. Our data support the use of the NASHA class of products in the treatment of knee OA.es_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.relation.ispartofInternational Journal of Molecular Scienceses_ES
dc.subjectKnee osteoarthritises_ES
dc.subjectHyalunonic acides_ES
dc.subjectStabilized hyaluronic acid (NASHA)es_ES
dc.subjectInyecciones intraarticulareses_ES
dc.subjectMasculinoes_ES
dc.subjectMediana edades_ES
dc.subjectOsteoartritis de la rodillaes_ES
dc.subjectDistribución aleatoriaes_ES
dc.subjectViscosuplementaciónes_ES
dc.subjectCostos de la atención en saludes_ES
dc.subjectAdultoes_ES
dc.subjectAncianoes_ES
dc.subjectFemeninoes_ES
dc.subjectHumanoses_ES
dc.subjectÁcido hialurónicoes_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Age Groups::Adultes_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Age Groups::Adult::Agedes_ES
dc.subject.meshMedical Subject Headings::Check Tags::Femalees_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Glycosaminoglycans::Hyaluronic Acides_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Injections::Injections, Intra-Articulares_ES
dc.subject.meshMedical Subject Headings::Check Tags::Malees_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Agedes_ES
dc.subject.meshMedical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Osteoarthritis::Osteoarthritis, Kneees_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Random Allocationes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Injections::Injections, Intra-Articular::Viscosupplementationes_ES
dc.subject.meshMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Delivery of Health Care::Health Care Costses_ES
dc.titleKnee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acides_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.versionYeses_ES
dc.identifier.pmid28304363es_ES
dc.rights.accessRightsAcceso abiertoes_ES
dc.identifier.doi10.3390/ijms18030658es_ES
dc.type.versioninfo:eu-repo/semantics/publishedes_ES
dc.relation.publisherversionhttp://www.mdpi.com/1422-0067/18/3/658es_ES
dc.contributor.authoraffiliation[Estades-Rubio, JF; García-Piriz,M; García-Vera,J; Montañez-Heredia,E] Department of Orthopedic Surgery and Traumatology, Virgen de la Victoria University Hospital, Málaga, Spain. [Reyes-Martín,A] Department of Orthopedic Surgery and Traumatology, Hospital Regional Universitario Carlos Haya, Malaga, Málaga, Spain. [Morales-Marcos,V] Department of Orthopedic Surgery and Traumatology, Hospital Quirónsalud Málaga, Málaga, Spain. [Perán,M] Department of Health Sciences, University of Jaén, Jaén, Spain. [Perán,M; Marchal,JA] Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research, University of Granada, Granada, Spain. [Marchal,JA] Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain. Biosanitary Institute of Granada (ibs. GRANADA), University Hospitals of Granada-University of Granada, Granada, Granada, Spain. [Montañez-Heredia,E] Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.es_ES
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

Files in This Item:
File Description SizeFormat 
EstadesRubioFJ_KneeViscosupplementation.pdfArtículo publicado246,64 kBAdobe PDFView/Open


This item is protected by original copyright



This item is licensed under a Creative Commons License Creative Commons