RT Journal Article
T1 Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid
A1 Estades-Rubio, Francisco J
A1 Reyes-Martín, Alvaro
A1 Morales-Marcos, Victor
A1 García-Piriz, Mercedes
A1 García-Vera, Juan J
A1 Perán, Macarena
A1 Marchal, Juan A
A1 Montañez-Heredia, Elvira
K1 Knee osteoarthritis
K1 Hyalunonic acid
K1 Stabilized hyaluronic acid (NASHA)
K1 Inyecciones intraarticulares
K1 Masculino
K1 Mediana edad
K1 Osteoartritis de la rodilla
K1 Distribución aleatoria
K1 Viscosuplementación
K1 Costos de la atención en salud
K1 Adulto
K1 Anciano
K1 Femenino
K1 Humanos
K1 Ácido hialurónico
AB Given the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II and III) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score greater than 7, with a homogeneous distribution of age, sex, BMI, and duration of disease, were included in this study. Patients were randomized into two groups: Group I was treated with NASHA (Durolane(®)) and Group II with HA (Go-ON(®)). Patient's evolution was followed up at the 1st, 2nd, 4th, 8th, 12th, and 26th week after treatment. A statistically significant improvement in WOMAC score was observed for patients treated with NASHA versus those who received HA at Week 26. In addition, the need for analgesia was significantly reduced at Week 26 in the NASHA-treated group. Finally, the economic analysis showed an increased cost of overall treatment with HA injections. Our data support the use of the NASHA class of products in the treatment of knee OA.
PB MDPI
YR 2017
FD 2017-03-17
LK http://hdl.handle.net/10668/2667
UL http://hdl.handle.net/10668/2667
LA en
NO Estades-Rubio FJ, Reyes-Martín A, Morales-Marcos V, García-Piriz M, García-Vera JJ, Perán M, et al.Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid.  Int J Mol Sci. 2017; 18(3).
DS RISalud
RD Apr 11, 2025