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Título : Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study.
Autor : Schütze, Madlen
Boeing, Heiner
Pischon, Tobias
Rehm, Jürgen
Kehoe, Tara
Gmel, Gerrit
Olsen, Anja
Tjønneland, Anne M
Dahm, Christina C
Overvad, Kim
Clavel-Chapelon, Françoise
Boutron-Ruault, Marie-Christine
Trichopoulou, Antonia
Benetou, Vasiliki
Zylis, Dimosthenis
Kaaks, Rudolf
Rohrmann, Sabine
Palli, Domenico
Berrino, Franco
Tumino, Rosario
Vineis, Paolo
Rodríguez, Laudina
Agudo, Antonio
Sánchez, María-José
Dorronsoro, Miren
Chirlaque, Maria-Dolores
Barricarte, Aurelio
Peeters, Petra H
van Gils, Carla H
Khaw, Kay-Tee
Wareham, Nick
Allen, Naomi E
Key, Timothy J
Boffetta, Paolo
Slimani, Nadia
Jenab, Mazda
Romaguera, Dora
Wark, Petra A
Riboli, Elio
Bergmann, Manuela M
Filiación: [Schuetze,M; Boeing,H; Pischon,T; Bergmann,MM.] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany. [Rehm,J; Kehoe,T; Gmel,G] CAMH, Toronto, ON, Canada. [Rehm, J] Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Dresden, Germany. [Olsen,A; Tjonneland,AM.] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Dahm,CC] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark. [Overvad,K] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark. [Clavel-Chapelon,F; Boutron-Ruault,M-C] Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth,Villejuif, France. [Clavel-Chapelon,F; Boutron-Ruault,MC] Paris S Univ, UMRS 1018, Villejuif, France. [Trichopoulou, A; Benetou,V; Zylis,D] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, Athens, Greece. [Kaaks,R; Rohrmann,S] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany. [Palli,D] Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy. [Berrino, Franco] Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Epidemiol Unit, Milan, Italy. [Tumino,R] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy. [Vineis, Paolo] Inst Sci Interchange Fdn, Turin, Italy. [Rodriguez,L] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain. [Tumino,R] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy. [Agudo,A] Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain. [Sanchez,MJ] Andalusian Sch Publ Hlth, Granada, Spain. [Sanchez,MJ; Dorronsoro,M; Chirlaque,MD; Barricarte,A] CIBERESP, San Sebastian, Spain. [Dorronsoro, Miren] Publ Hlth Dept Gipuzkoa, San Sebastian, Spain. [Chirlaque,MD] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain. [Peeters,PH.;van Gils,CH.] Univ Med Ctr, Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Khaw,K_T] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England. [Wareham,N] MRC, Epidemiol Unit, Cambridge, England. [Allen,NE.;Key,TJ.] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, England. [Boffetta, P;Slimani,N;Jenab,M] Int Agcy Res Canc, Lyon, France. [Boffetta,P] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA. [Vineis,P; Romaguera,D; Wark,PA.; Riboli,E] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
Palabras clave : Incidencia
Quantitative research
Alcohol drinking
Consumo de bebidas alcohólicas
Breast cancer
Colon cancer
MeSH: Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Diseases::Neoplasms
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Health Education
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques
Fecha de publicación : 7-Apr-2011
Editorial : BMJ Publishing Group
Cita Bibliográfica: Schütze M, Boeing H, Pischon T, Rehm J, Kehoe T, Gmel G, et al. Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study. BMJ. 2011 Apr 7; 342:d1584
Abstract: Objective To compute the burden of cancer attributable to current and former alcohol consumption in eight European countries based on direct relative risk estimates from a cohort study. Design Combination of prospective cohort study with representative population based data on alcohol exposure. Setting Eight countries (France, Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Denmark) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Participants 109 118 men and 254 870 women, mainly aged 37-70. Main outcome measures Hazard rate ratios expressing the relative risk of cancer incidence for former and current alcohol consumption among EPIC participants. Hazard rate ratios combined with representative information on alcohol consumption to calculate alcohol attributable fractions of causally related cancers by country and sex. Partial alcohol attributable fractions for consumption higher than the recommended upper limit (two drinks a day for men with about 24 g alcohol, one for women with about 12 g alcohol) and the estimated total annual number of cases of alcohol attributable cancer. Results If we assume causality, among men and women, 10% (95% confidence interval 7 to 13%) and 3% (1 to 5%) of the incidence of total cancer was attributable to former and current alcohol consumption in the selected European countries. For selected cancers the figures were 44% (31 to 56%) and 25% (5 to 46%) for upper aerodigestive tract, 33% (11 to 54%) and 18% (−3 to 38%) for liver, 17% (10 to 25%) and 4% (−1 to 10%) for colorectal cancer for men and women, respectively, and 5.0% (2 to 8%) for female breast cancer. A substantial part of the alcohol attributable fraction in 2008 was associated with alcohol consumption higher than the recommended upper limit: 33 037 of 178 578 alcohol related cancer cases in men and 17 470 of 397 043 alcohol related cases in women. Conclusions In western Europe, an important proportion of cases of cancer can be attributable to alcohol consumption, especially consumption higher than the recommended upper limits. These data support current political efforts to reduce or to abstain from alcohol consumption to reduce the incidence of cancer.
Versión del editor :
DOI: 10.1136/bmj.d1584
Appears in Collections:01- Artículos - EASP. Escuela Andaluza de Salud Pública

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