RT Journal Article
T1 Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study.
A1 Schütze, Madlen
A1 Boeing, Heiner
A1 Pischon, Tobias
A1 Rehm, Jürgen
A1 Kehoe, Tara
A1 Gmel, Gerrit
A1 Olsen, Anja
A1 Tjønneland, Anne M
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Clavel-Chapelon, Françoise
A1 Boutron-Ruault, Marie-Christine
A1 Trichopoulou, Antonia
A1 Benetou, Vasiliki
A1 Zylis, Dimosthenis
A1 Kaaks, Rudolf
A1 Rohrmann, Sabine
A1 Palli, Domenico
A1 Berrino, Franco
A1 Tumino, Rosario
A1 Vineis, Paolo
A1 Rodríguez, Laudina
A1 Agudo, Antonio
A1 Sanchez-Perez, Maria-Jose
A1 Dorronsoro, Miren
A1 Chirlaque, Maria-Dolores
A1 Barricarte, Aurelio
A1 Peeters, Petra H
A1 van Gils, Carla H
A1 Khaw, Kay-Tee
A1 Wareham, Nick
A1 Allen, Naomi E
A1 Key, Timothy J
A1 Boffetta, Paolo
A1 Slimani, Nadia
A1 Jenab, Mazda
A1 Romaguera, Dora
A1 Wark, Petra A
A1 Riboli, Elio
A1 Bergmann, Manuela M
K1 Incidencia
K1 Quantitative research
K1 Alcohol drinking
K1 Consumo de bebidas alcohólicas
K1 Breast cancer
K1 Colon cancer
K1 Oncology
AB Objective To compute the burden of cancer attributable to current and former alcohol consumption in eight European countries based on direct relative risk estimates from a cohort study.Design Combination of prospective cohort study with representative population based data on alcohol exposure.Setting Eight countries (France, Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Denmark) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Participants 109 118 men and 254 870 women, mainly aged 37-70.Main outcome measures Hazard rate ratios expressing the relative risk of cancer incidence for former and current alcohol consumption among EPIC participants. Hazard rate ratios combined with representative information on alcohol consumption to calculate alcohol attributable fractions of causally related cancers by country and sex. Partial alcohol attributable fractions for consumption higher than the recommended upper limit (two drinks a day for men with about 24 g alcohol, one for women with about 12 g alcohol) and the estimated total annual number of cases of alcohol attributable cancer.Results If we assume causality, among men and women, 10% (95% confidence interval 7 to 13%) and 3% (1 to 5%) of the incidence of total cancer was attributable to former and current alcohol consumption in the selected European countries. For selected cancers the figures were 44% (31 to 56%) and 25% (5 to 46%) for upper aerodigestive tract, 33% (11 to 54%) and 18% (−3 to 38%) for liver, 17% (10 to 25%) and 4% (−1 to 10%) for colorectal cancer for men and women, respectively, and 5.0% (2 to 8%) for female breast cancer. A substantial part of the alcohol attributable fraction in 2008 was associated with alcohol consumption higher than the recommended upper limit: 33 037 of 178 578 alcohol related cancer cases in men and 17 470 of 397 043 alcohol related cases in women.Conclusions In western Europe, an important proportion of cases of cancer can be attributable to alcohol consumption, especially consumption higher than the recommended upper limits. These data support current political efforts to reduce or to abstain from alcohol consumption to reduce the incidence of cancer.
PB BMJ Publishing Group
YR 2011
FD 2011-04-07
LK http://hdl.handle.net/10668/243
UL http://hdl.handle.net/10668/243
LA en
NO Schütze M, Boeing H, Pischon T, Rehm J, Kehoe T, Gmel G, et al. Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study. BMJ. 2011 Apr 7; 342:d1584
DS RISalud
RD Apr 18, 2025