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http://hdl.handle.net/10668/13905
Title: | Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. |
Authors: | Sanikini, Harinakshi Muller, David C Sophiea, Marisa Rinaldi, Sabina Agudo, Antonio Duell, Eric J Weiderpass, Elisabete Overvad, Kim Tjønneland, Anne Halkjaer, Jytte Boutron-Ruault, Marie-Christine Carbonnel, Franck Cervenka, Iris Boeing, Heiner Kaaks, Rudolf Kühn, Tilman Trichopoulou, Antonia Martimianaki, Georgia Karakatsani, Anna Pala, Valeria Palli, Domenico Mattiello, Amalia Tumino, Rosario Sacerdote, Carlotta Skeie, Guri Rylander, Charlotta Chirlaque López, María-Dolores Sánchez, Maria-Jose Ardanaz, Eva Regnér, Sara Stocks, Tanja Bueno-de-Mesquita, Bas Vermeulen, Roel C H Aune, Dagfinn Tong, Tammy Y N Kliemann, Nathalie Murphy, Neil Chadeau-Hyam, Marc Gunter, Marc J Cross, Amanda J |
Keywords: | cancer;esophageal;gastric;hormones;obesity;reproductive |
metadata.dc.subject.mesh: | Anthropometry Body Fat Distribution Cohort Studies Esophageal Neoplasms Europe Female Humans Male Middle Aged Proportional Hazards Models Prospective Studies Reproductive History Risk Factors Stomach Neoplasms |
Issue Date: | 21-May-2019 |
Abstract: | Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5-25 kg/m2 : HR = 1.94, 95% CI: 1.25-3.03) and women (HR = 2.66, 95% CI: 1.15-6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99-6.06 for WHR >0.96 vs. 0.96 vs. 98 vs. 0.82 vs. 84 vs. 2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32-0.91; >26 vs. 26 vs. |
URI: | http://hdl.handle.net/10668/13905 |
metadata.dc.identifier.doi: | 10.1002/ijc.32386 |
Appears in Collections: | Producción 2020 |
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