RT Journal Article
T1 Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
A1 Sanikini, Harinakshi
A1 Muller, David C
A1 Sophiea, Marisa
A1 Rinaldi, Sabina
A1 Agudo, Antonio
A1 Duell, Eric J
A1 Weiderpass, Elisabete
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Halkjaer, Jytte
A1 Boutron-Ruault, Marie-Christine
A1 Carbonnel, Franck
A1 Cervenka, Iris
A1 Boeing, Heiner
A1 Kaaks, Rudolf
A1 Kühn, Tilman
A1 Trichopoulou, Antonia
A1 Martimianaki, Georgia
A1 Karakatsani, Anna
A1 Pala, Valeria
A1 Palli, Domenico
A1 Mattiello, Amalia
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Skeie, Guri
A1 Rylander, Charlotta
A1 Chirlaque Lopez, Maria-Dolores
A1 Sanchez-Perez, Maria-Jose
A1 Ardanaz, Eva
A1 Regner, Sara
A1 Stocks, Tanja
A1 Bueno-de-Mesquita, Bas
A1 Vermeulen, Roel C H
A1 Aune, Dagfinn
A1 Tong, Tammy Y N
A1 Kliemann, Nathalie
A1 Murphy, Neil
A1 Chadeau-Hyam, Marc
A1 Gunter, Marc J
A1 Cross, Amanda J
K1 cancer
K1 esophageal
K1 gastric
K1 hormones
K1 obesity
K1 reproductive
AB Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5-25 kg/m2 : HR = 1.94, 95% CI: 1.25-3.03) and women (HR = 2.66, 95% CI: 1.15-6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99-6.06 for WHR >0.96 vs. 0.96 vs. 98 vs. 0.82 vs. 84 vs. 2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32-0.91; >26 vs. 26 vs.
PB John Wiley & Sons, Inc
YR 2019
FD 2019-03-28
LK http://hdl.handle.net/10668/13905
UL http://hdl.handle.net/10668/13905
LA en
NO Sanikini H, Muller DC, Sophiea M, Rinaldi S, Agudo A, Duell EJ, et al. Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Int J Cancer. 2020 Feb 15;146(4):929-942.
NO This research was funded by the Stand Up to Cancer campaign for Cancer Research UK. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l'Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM, France); German Cancer Aid, German Cancer Research Centre (DKFZ), Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); National Institute for Public Health and the Environment (Bilthoven, The Netherlands) for their contribution to data collection; Health Research Fund (FIS), PI13/00061 to Granada, PI13/01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia (no. 6236) and the Catalan Institute of Oncology (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to KTK, NJW; C570/A16491 to RCT and C8221/A19170 to TK [EPIC-Oxford]), Medical Research Council (1000143 to KTK, NJW, MR/M012190/1 to TK [EPIC-Oxford, United Kingdom]).
DS RISalud
RD Apr 6, 2025