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Title: Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition.
Authors: Costas, Laura
Lujan-Barroso, Leila
Benavente, Yolanda
Allen, Naomi E
Amiano, Pilar
Ardanaz, Eva
Besson, Caroline
Boeing, Heiner
Bueno-de-Mesquita, Bas
Cervenka, Iris
Fortner, Renée T
Fournier, Agnès
Gunter, Marc
Harlid, Sophia
Huerta, José María
Jerkeman, Mats
Jirström, Karin
Kaaks, Rudolf
Karakatsani, Anna
Khaw, Kay-Tee
Kotanidou, Anastasia
Lund, Eiliv
Masala, Giovanna
Mattiello, Amalia
Melin, Beatrice
Menéndez, Virginia
Murphy, Neil
Nieters, Alexandra
Overvad, Kim
Riboli, Elio
Sacerdote, Carlotta
Sánchez, Maria-Jose
Schmidt, Julie A
Sieri, Sabina
Tjønneland, Anne
Trichopoulou, Antonia
Tumino, Rosario
Vermeulen, Roel
Weiderpass, Elisabete
de Sanjosé, Silvia
Agudo, Antonio
Casabonne, Delphine
metadata.dc.subject.mesh: Breast Feeding
Estrogen Replacement Therapy
Lymphoma, B-Cell
Proportional Hazards Models
Prospective Studies
Reproductive History
Risk Factors
Women's Health
Issue Date: 2019
Abstract: The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.
metadata.dc.identifier.doi: 10.1093/aje/kwy259
Appears in Collections:Producción 2020

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