RT Journal Article
T1 Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition.
A1 Costas, Laura
A1 Lujan-Barroso, Leila
A1 Benavente, Yolanda
A1 Allen, Naomi E
A1 Amiano, Pilar
A1 Ardanaz, Eva
A1 Besson, Caroline
A1 Boeing, Heiner
A1 Bueno-de-Mesquita, Bas
A1 Cervenka, Iris
A1 Fortner, Renée T
A1 Fournier, Agnès
A1 Gunter, Marc
A1 Harlid, Sophia
A1 Huerta, José María
A1 Jerkeman, Mats
A1 Jirström, Karin
A1 Kaaks, Rudolf
A1 Karakatsani, Anna
A1 Khaw, Kay-Tee
A1 Kotanidou, Anastasia
A1 Lund, Eiliv
A1 Masala, Giovanna
A1 Mattiello, Amalia
A1 Melin, Beatrice
A1 Menéndez, Virginia
A1 Murphy, Neil
A1 Nieters, Alexandra
A1 Overvad, Kim
A1 Riboli, Elio
A1 Sacerdote, Carlotta
A1 Sanchez-Perez, Maria-Jose
A1 Schmidt, Julie A
A1 Sieri, Sabina
A1 Tjønneland, Anne
A1 Trichopoulou, Antonia
A1 Tumino, Rosario
A1 Vermeulen, Roel
A1 Weiderpass, Elisabete
A1 de Sanjosé, Silvia
A1 Agudo, Antonio
A1 Casabonne, Delphine
AB The role of hormonal factors in the etiology of lymphoid neoplasms remains unclear. Previous studies have yielded conflicting results, have lacked sufficient statistical power to assess many lymphoma subtypes, or have lacked detailed information on relevant exposures. Within the European Prospective Investigation Into Cancer and Nutrition cohort, we analyzed comprehensive data on reproductive factors and exogenous hormone use collected at baseline (1992-2000) among 343,458 women, including data on 1,427 incident cases of B-cell non-Hodgkin lymphoma (NHL) and its major subtypes identified after a mean follow-up period of 14 years (through 2015). We estimated hazard ratios and 95% confidence intervals using multivariable proportional hazards modeling. Overall, we observed no statistically significant associations between parity, age at first birth, breastfeeding, oral contraceptive use, or ever use of postmenopausal hormone therapy and risk of B-cell NHL or its subtypes. Women who had undergone surgical menopause had a 51% higher risk of B-cell NHL (based on 67 cases) than women with natural menopause (hazard ratio = 1.51, 95% confidence interval: 1.17, 1.94). Given that this result may have been due to chance, our results provide little support for the hypothesis that sex hormones play a role in lymphomagenesis.
YR 2019
FD 2019
LK http://hdl.handle.net/10668/13244
UL http://hdl.handle.net/10668/13244
LA en
DS RISalud
RD Apr 15, 2025