Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1298
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLangenberg, Claudia-
dc.contributor.authorSharp, Stephen J-
dc.contributor.authorSchulze, Matthias B-
dc.contributor.authorRolandsson, Olov-
dc.contributor.authorOvervad, Kim-
dc.contributor.authorForouhi, Nita G-
dc.contributor.authorSpranger, Joachim-
dc.contributor.authorDrogan, Dagmar-
dc.contributor.authorHuerta, José María-
dc.contributor.authorArriola, Larraitz-
dc.contributor.authorde Lauzon-Guillan, Blandine-
dc.contributor.authorTormo, Maria-Jose-
dc.contributor.authorArdanaz, Eva-
dc.contributor.authorBalkau, Beverley-
dc.contributor.authorBeulens, Joline W J-
dc.contributor.authorBoeing, Heiner-
dc.contributor.authorBueno-de-Mesquita, H Bas-
dc.contributor.authorClavel-Chapelon, Françoise-
dc.contributor.authorCrowe, Francesca L-
dc.contributor.authorFranks, Paul W-
dc.contributor.authorGonzalez, Carlos A-
dc.contributor.authorGrioni, Sara-
dc.contributor.authorHalkjaer, Jytte-
dc.contributor.authorHallmans, Goran-
dc.contributor.authorKaaks, Rudolf-
dc.contributor.authorKerrison, Nicola D-
dc.contributor.authorKey, Timothy J-
dc.contributor.authorKhaw, Kay Tee-
dc.contributor.authorMattiello, Amalia-
dc.contributor.authorNilsson, Peter-
dc.contributor.authorNorat, Teresa-
dc.contributor.authorPalla, Luigi-
dc.contributor.authorPalli, Domenico-
dc.contributor.authorPanico, Salvatore-
dc.contributor.authorQuirós, J Ramón-
dc.contributor.authorRomaguera, Dora-
dc.contributor.authorRomieu, Isabelle-
dc.contributor.authorSacerdote, Carlotta-
dc.contributor.authorSánchez, María-José-
dc.contributor.authorSlimani, Nadia-
dc.contributor.authorSluijs, Ivonne-
dc.contributor.authorSpijkerman, Annemieke M W-
dc.contributor.authorTeucher, Birgit-
dc.contributor.authorTjonneland, Anne-
dc.contributor.authorTumino, Rosario-
dc.contributor.authorvan der A, Daphne L-
dc.contributor.authorvan der Schouw, Yvonne T-
dc.contributor.authorFeskens, Edith J M-
dc.contributor.authorRiboli, Elio-
dc.contributor.authorWareham, Nicholas J-
dc.contributor.authorSchulze, Matthias B.-
dc.date.accessioned2013-09-26T09:47:15Z-
dc.date.available2013-09-26T09:47:15Z-
dc.date.issued2012-06-05-
dc.identifier.citationLangenberg C, Sharp SJ, Schulze MB, Rolandsson O, Overvad K, Forouhi NG, et al. Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study. PLoS Med. 2012; 9(6) e1001230es
dc.identifier.issn1549-1676 (Online)-
dc.identifier.issn1549-1277 (Print)-
dc.identifier.otherPMC3367997-
dc.identifier.urihttp://hdl.handle.net/10668/1298-
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractBACKGROUND Waist circumference (WC) is a simple and reliable measure of fat distribution that may add to the prediction of type 2 diabetes (T2D), but previous studies have been too small to reliably quantify the relative and absolute risk of future diabetes by WC at different levels of body mass index (BMI). METHODS AND FINDINGS The prospective InterAct case-cohort study was conducted in 26 centres in eight European countries and consists of 12,403 incident T2D cases and a stratified subcohort of 16,154 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. We used Prentice-weighted Cox regression and random effects meta-analysis methods to estimate hazard ratios for T2D. Kaplan-Meier estimates of the cumulative incidence of T2D were calculated. BMI and WC were each independently associated with T2D, with WC being a stronger risk factor in women than in men. Risk increased across groups defined by BMI and WC; compared to low normal weight individuals (BMI 18.5-22.4 kg/m(2)) with a low WC (<94/80 cm in men/women), the hazard ratio of T2D was 22.0 (95% confidence interval 14.3; 33.8) in men and 31.8 (25.2; 40.2) in women with grade 2 obesity (BMI≥35 kg/m(2)) and a high WC (>102/88 cm). Among the large group of overweight individuals, WC measurement was highly informative and facilitated the identification of a subgroup of overweight people with high WC whose 10-y T2D cumulative incidence (men, 70 per 1,000 person-years; women, 44 per 1,000 person-years) was comparable to that of the obese group (50-103 per 1,000 person-years in men and 28-74 per 1,000 person-years in women). CONCLUSIONS WC is independently and strongly associated with T2D, particularly in women, and should be more widely measured for risk stratification. If targeted measurement is necessary for reasons of resource scarcity, measuring WC in overweight individuals may be an effective strategy, since it identifies a high-risk subgroup of individuals who could benefit from individualised preventive action.es
dc.description.sponsorshipFunding: EU Integrated Project LSHM-CT-2006-037197. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. InterAct investigators acknowledge funding from the following agencies: KO: Danish Cancer Society; JS: ‘Heisenberg-Professorship (SP716/2-1), clinical research group (KFO218/1), and a research group (Molecular Nutrition to JS) support of the Bundesministerium fu¨ r Bildung und Forschung (BMBF); MJT: Health Research Fund (FIS) of the Spanish Ministry of Health; the CIBER en Epidemiologı´a y Salud Pu´ blica (CIBERESP), Spain, Murcia Regional Government (Nu 6236); JWJB, HBBdM, IS, AMWS, DLvdA, YTvdS: Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands; verification of diabetes cases was additionally funded by NL Agency grant IGE05012 and an Incentive Grant from the Board of the UMC Utrecht; FLC: Cancer Research UK; PWF: Swedish Research Council, Novo Nordisk, Swedish Diabetes Association, Swedish Heart-Lung Foundation; GH: The county of Va¨sterbotten; RK: German Cancer Aid, Federal Ministry of Education and Research; TJK: Cancer Research UK; KK: Medical Research Council UK, Cancer Research UK; PN: Swedish Research Council; JRQ: Asturias Regional Government; BT: German Cancer Aid; Federal Ministry of Education and Research; AT: Danish Cancer Society; RT: AIRE-ONLUS Ragusa, AVIS-Ragusa, Sicilian Regional Government.es
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPLoS medicinees
dc.subjectAntropometríaes
dc.subjectÍndice de Masa Corporales
dc.subjectDiabetes Mellitus Tipo 2es
dc.subjectEstudios de Cohorteses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Anthropometryes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Indexes
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2es
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studieses
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidencees
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesityes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Modelses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factorses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time Factorses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Waist Circumferencees
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europees
dc.titleLong-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort studyes
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.contributor.groupThe InterAct Consortiumes
dc.identifier.pmid22679397-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1371/journal.pmed.1001230-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001230es
dc.contributor.authoraffiliation[Langenberg,C; Sharp,SJ; Forouhi,NG; Kerrison,ND; Palla,L; Wareham,NJ] MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom. [Schulze,MB] Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur-Scheunert-Allee, Nuthetal, Germany. [Rolandsson,O; Hallmans,G] Department of Public Health and Clinical Medicine, Umea University, Norrlands Universitetsjukhus, Umea, Sweden. [Overvad,K] Department of Epidemiology, School of Public Health, Aarhus C, Denmark. [Spranger.J] Charité-Universitatsmedizin Berlin, Department of Endocrinology, Diabetes and Nutrition, Berlin, Germany. [Drogan,D; Boeing,H] Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.[Arriola,L; Tormo,MJ] Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. [Huerta,JM; Arriola,L; Tormo,MJ; Ardanaz,E; Sánchez,MJ] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pu´ blica), Madrid, Spain . [Arriola,L] Public Health Division of Gipuzkoa, Basque Government, San Sebastian, Spain. Instituto BIO-Donostia, Hospital Donostia, Donostia, Basque Country. [Lauzon-Guillan,B; Balkau,B] INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018: Epidemiology of Diabetes, Obesity and Chronic Kidney Disease over the Lifecourse, Villejuif Cedex, France. University Paris, Villejuif Cedex, France. [Ardanaz,E] Navarre Public Health Institute, Pamplona, Navarra, Spain. [Beulens,JWJ; Sluijs,I; Schouw,T] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. [Bueno-de-Mesquita,HB] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [Clavel-Chapelon,F] INSERM, CESP Centre for Research in Epidemiology and Population Health,U1018: Nutrition, Hormones and Women’s Health, IGR, Villejuif Cedex, France. [Crowe,FL; Key,TJ] Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford,Richard Doll Building, Roosevelt Drive, Oxford, United Kingdom. [Grioni,S] Fondazione IRCCS Istituto Nazionale Tumori Milan, Milan, Italy. [Halkjaer,J; Tjonneland,A] Danish Cancer Society Research Center, Copenhagen, Denmark. [Kerrison,ND; Teucher,B] German Cancer Research Centre, Heidelberg, Germany. [Khaw,KT] Department of Public Health and Primary Care, University of Cambridge Addenbrooke’s Hospital, Cambridge, United Kingdom. [Mattiello,A] Department of Clinical and Experimental Medicine Federico II University, Naples, Italy. [Nilsson,P; Panico,S] University of Lund, Department of Clinical Sciences Medicine, University Hospital Scania, Malmo, Sweden. [Norat,T; Romaguera,D; Riboli,E] Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. [Palli,D] Molecular and Nutritional Epidemiology Unit, ISPO Ponte Nuovo, Florence, Italy. [Quirós, JR] Public Health Directorate, Oviedo, Spain. [Romieu,I; Slimani,N] International Agency for Research on Cancer, Lyon Cedex, France. [Sacerdote,C] Center for Cancer Prevention (CPO-Piemonte), Torino, Italy. Human Genetics Foundation (HuGeF), Torino, Italy. [Sánchez,MJ] Andalusian School of Public Health, Granada, Spain. [Spijkerman,AMW; A Daphne,L] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [Tumino,R] Cancer Registry and Histopathology Unit, ‘‘Civile - M.P. Arezzo’’ Hospital, Dante Ragusa, Italy. [Feskens,EJM] Division of Human Nutrition - Section Nutrition and Epidemiology, University of Wageningen, Wageningen, The Netherlands. [Franks,PW] Department of Clinical Sciences, Clinical Research Center, Ska°ne University Hospital, Lund University, Malmö , Sweden. [Bueno-de-Mesquita,HB] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - EASP. Escuela Andaluza de Salud Pública

Files in This Item:
File Description SizeFormat 
Langenberg_Lon-Term.pdf740,44 kBAdobe PDFView/Open
journal.pmed.1001230.s001.tif404,9 kBTIFFView/Open
journal.pmed.1001230.s002.doc56,5 kBMicrosoft WordView/Open
journal.pmed.1001230.s003.doc49 kBMicrosoft WordView/Open


This item is protected by original copyright



Except where otherwise noted, Items on the Andalusian Health Repository site are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives License.