RT Journal Article
T1 Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study
A1 Langenberg, Claudia
A1 Sharp, Stephen J
A1 Schulze, Matthias B
A1 Rolandsson, Olov
A1 Overvad, Kim
A1 Forouhi, Nita G
A1 Spranger, Joachim
A1 Drogan, Dagmar
A1 Huerta, José María
A1 Arriola, Larraitz
A1 de Lauzon-Guillan, Blandine
A1 Tormo, Maria-Jose
A1 Ardanaz, Eva
A1 Balkau, Beverley
A1 Beulens, Joline W J
A1 Boeing, Heiner
A1 Bueno-de-Mesquita, H Bas
A1 Clavel-Chapelon, Françoise
A1 Crowe, Francesca L
A1 Franks, Paul W
A1 Gonzalez, Carlos A
A1 Grioni, Sara
A1 Halkjaer, Jytte
A1 Hallmans, Goran
A1 Kaaks, Rudolf
A1 Kerrison, Nicola D
A1 Key, Timothy J
A1 Khaw, Kay Tee
A1 Mattiello, Amalia
A1 Nilsson, Peter
A1 Norat, Teresa
A1 Palla, Luigi
A1 Palli, Domenico
A1 Panico, Salvatore
A1 Quirós, J Ramón
A1 Romaguera, Dora
A1 Romieu, Isabelle
A1 Sacerdote, Carlotta
A1 Sanchez-Perez, Maria-Jose
A1 Slimani, Nadia
A1 Sluijs, Ivonne
A1 Spijkerman, Annemieke M W
A1 Teucher, Birgit
A1 Tjonneland, Anne
A1 Tumino, Rosario
A1 van der A, Daphne L
A1 van der Schouw, Yvonne T
A1 Feskens, Edith J M
A1 Riboli, Elio
A1 Wareham, Nicholas J
A1 Schulze, Matthias B.
K1 Antropometría
K1 Índice de Masa Corporal
K1 Diabetes Mellitus Tipo 2
K1 Estudios de Cohortes
AB BACKGROUNDWaist circumference (WC) is a simple and reliable measure of fat distribution that may add to the prediction of type 2 diabetes (T2D), but previous studies have been too small to reliably quantify the relative and absolute risk of future diabetes by WC at different levels of body mass index (BMI).METHODS AND FINDINGSThe prospective InterAct case-cohort study was conducted in 26 centres in eight European countries and consists of 12,403 incident T2D cases and a stratified subcohort of 16,154 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. We used Prentice-weighted Cox regression and random effects meta-analysis methods to estimate hazard ratios for T2D. Kaplan-Meier estimates of the cumulative incidence of T2D were calculated. BMI and WC were each independently associated with T2D, with WC being a stronger risk factor in women than in men. Risk increased across groups defined by BMI and WC; compared to low normal weight individuals (BMI 18.5-22.4 kg/m(2)) with a low WC (<94/80 cm in men/women), the hazard ratio of T2D was 22.0 (95% confidence interval 14.3; 33.8) in men and 31.8 (25.2; 40.2) in women with grade 2 obesity (BMI≥35 kg/m(2)) and a high WC (>102/88 cm). Among the large group of overweight individuals, WC measurement was highly informative and facilitated the identification of a subgroup of overweight people with high WC whose 10-y T2D cumulative incidence (men, 70 per 1,000 person-years; women, 44 per 1,000 person-years) was comparable to that of the obese group (50-103 per 1,000 person-years in men and 28-74 per 1,000 person-years in women).CONCLUSIONSWC is independently and strongly associated with T2D, particularly in women, and should be more widely measured for risk stratification. If targeted measurement is necessary for reasons of resource scarcity, measuring WC in overweight individuals may be an effective strategy, since it identifies a high-risk subgroup of individuals who could benefit from individualised preventive action.
PB Public Library of Science
SN 1549-1277
YR 2012
FD 2012-06-05
LK http://hdl.handle.net/10668/1298
UL http://hdl.handle.net/10668/1298
LA en
NO Langenberg C, Sharp SJ, Schulze MB, Rolandsson O, Overvad K, Forouhi NG, et al. Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study. PLoS Med. 2012; 9(6) e1001230
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 19, 2025