Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1158
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dc.contributor.authorGarrido-Sánchez, Lourdes-
dc.contributor.authorGarcía-Fuentes, Eduardo-
dc.contributor.authorFernández-García, Diego-
dc.contributor.authorEscoté, Xavier-
dc.contributor.authorAlcaide, Juan-
dc.contributor.authorPérez-Martínez, Pablo-
dc.contributor.authorVendrell, Joan-
dc.contributor.authorTinahones, Francisco J-
dc.date.accessioned2013-06-24T10:57:08Z-
dc.date.available2013-06-24T10:57:08Z-
dc.date.issued2012-03-19-
dc.identifier.citationGarrido-Sánchez L, García-Fuentes E, Fernández-García D, Escoté X, Alcaide J, Pérez-Martínez P, et al. Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients. PLoS ONE. 2012; 7(3):e33264es
dc.identifier.issn1932-6203 (Online)-
dc.identifier.otherPMC3307730-
dc.identifier.urihttp://hdl.handle.net/10668/1158-
dc.descriptionClinical Trial; Journal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractOBJECTIVE Zinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR). METHODS mRNA expression levels of PPARγ, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed. RESULTS The morbidly obese patients with low IR had a higher VAT ZAG expression as compared with the patients with high IR (p = 0.023). In the patients with low IR, the VAT ZAG expression was greater than that in SAT (p = 0.009). ZAG expression correlated between SAT and VAT (r = 0.709, p<0.001). VAT ZAG expression was mainly predicted by insulin, HOMA-IR, plasma adiponectin and expression of adiponectin and ACSS2. SAT ZAG expression was only predicted by expression of ATGL. CONCLUSIONS ZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance. These findings suggest that ZAG may be a useful target in obesity and related disorders, such as diabetes.es
dc.description.sponsorshipThis work was supported in part by grants from the Programa Juan de la Cierva (JCI-2009-04086), Instituto de Salud Carlos III (CP04/00133, PS09/01060, PS09/00997), Servicio Andaluz de Salud (PI0255/2007).es
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPloS onees
dc.subjectIRS1 protein, humanes
dc.subjectZn-alpha-2-glycoproteines
dc.subjectmarneral synthase, Arabidopsises
dc.subjectProteínas de Arabidopsises
dc.subjectRegulación de la Expresión Génicaes
dc.subjectProteínas Sustrato del Receptor de Insulinaes
dc.subjectResistencia a la Insulinaes
dc.subjectGrasa Intraabdominales
dc.subjectTransferasas Intramoleculareses
dc.subjectLipólisises
dc.subjectObesidad Mórbidaes
dc.subjectProteínas de Plasma Seminales
dc.subjectGrasa Subcutáneaes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Plant Proteins::Arabidopsis Proteinses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulationes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::Insulin Receptor Substrate Proteinses
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistancees
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Abdominal Fat::Intra-Abdominal Fates
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Isomerases::Intramolecular Transferaseses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Lipolysises
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Obesity, Morbides
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated Receptors::PPAR gammaes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Seminal Plasma Proteinses
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Subcutaneous Fates
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.titleZinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients.es
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid22442679-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1371/journal.pone.0033264-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033264es
dc.contributor.authoraffiliation[Garrido-Sánchez,L; Escoté,X; Vendrell,J] CIBERDEM, Hospital Universitari Joan XXIII, Pere Virgili Institute, Tarragona, Spain. [García-Fuentes,E; AlcaideJ] Fundación IMABIS, Málaga, Spain. [García-Fuentes,E; Fernández-García,D; Pérez-Martínez,P] Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN), Málaga, Spain. [Alcaide,J; Tinahones,FJ] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Pérez-Martínez,P] Servicio de Medicina Interna, Hospital Universitario Reina Sofía, Córdoba, Spain.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital Reina Sofía
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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