RT Journal Article
T1 Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients.
A1 Garrido-Sánchez, Lourdes
A1 García-Fuentes, Eduardo
A1 Fernández-García, Diego
A1 Escoté, Xavier
A1 Alcaide, Juan
A1 Pérez-Martínez, Pablo
A1 Vendrell, Joan
A1 Tinahones, Francisco J
K1 IRS1 protein, human
K1 Zn-alpha-2-glycoprotein
K1 marneral synthase, Arabidopsis
K1 Proteínas de Arabidopsis
K1 Regulación de la Expresión Génica
K1 Proteínas Sustrato del Receptor de Insulina
K1 Resistencia a la Insulina
K1 Grasa Intraabdominal
K1 Transferasas Intramoleculares
K1 Lipólisis
K1 Obesidad Mórbida
K1 Proteínas de Plasma Seminal
K1 Grasa Subcutánea
AB OBJECTIVEZinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR).METHODSmRNA expression levels of PPARγ, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed.RESULTSThe morbidly obese patients with low IR had a higher VAT ZAG expression as compared with the patients with high IR (p = 0.023). In the patients with low IR, the VAT ZAG expression was greater than that in SAT (p = 0.009). ZAG expression correlated between SAT and VAT (r = 0.709, p<0.001). VAT ZAG expression was mainly predicted by insulin, HOMA-IR, plasma adiponectin and expression of adiponectin and ACSS2. SAT ZAG expression was only predicted by expression of ATGL.CONCLUSIONSZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance. These findings suggest that ZAG may be a useful target in obesity and related disorders, such as diabetes.
PB Public Library of Science
YR 2012
FD 2012-03-19
LK http://hdl.handle.net/10668/1158
UL http://hdl.handle.net/10668/1158
LA en
NO Garrido-Sánchez L, García-Fuentes E, Fernández-García D, Escoté X, Alcaide J, Pérez-Martínez P, et al. Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients. PLoS ONE. 2012; 7(3):e33264
NO Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 9, 2025