Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1158
Title: Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients.
Authors: Garrido-Sánchez, Lourdes
García-Fuentes, Eduardo
Fernández-García, Diego
Escoté, Xavier
Alcaide, Juan
Pérez-Martínez, Pablo
Vendrell, Joan
Tinahones, Francisco J
metadata.dc.contributor.authoraffiliation: [Garrido-Sánchez,L; Escoté,X; Vendrell,J] CIBERDEM, Hospital Universitari Joan XXIII, Pere Virgili Institute, Tarragona, Spain. [García-Fuentes,E; AlcaideJ] Fundación IMABIS, Málaga, Spain. [García-Fuentes,E; Fernández-García,D; Pérez-Martínez,P] Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN), Málaga, Spain. [Alcaide,J; Tinahones,FJ] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Pérez-Martínez,P] Servicio de Medicina Interna, Hospital Universitario Reina Sofía, Córdoba, Spain.
Keywords: IRS1 protein, human;Zn-alpha-2-glycoprotein;marneral synthase, Arabidopsis;Proteínas de Arabidopsis;Regulación de la Expresión Génica;Proteínas Sustrato del Receptor de Insulina;Resistencia a la Insulina;Grasa Intraabdominal;Transferasas Intramoleculares;Lipólisis;Obesidad Mórbida;Proteínas de Plasma Seminal;Grasa Subcutánea
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Plant Proteins::Arabidopsis Proteins
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::Insulin Receptor Substrate Proteins
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance
Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Abdominal Fat::Intra-Abdominal Fat
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Isomerases::Intramolecular Transferases
Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Lipolysis
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Obesity, Morbid
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated Receptors::PPAR gamma
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Seminal Plasma Proteins
Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Subcutaneous Fat
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Issue Date: 19-Mar-2012
Publisher: Public Library of Science
Citation: Garrido-Sánchez L, García-Fuentes E, Fernández-García D, Escoté X, Alcaide J, Pérez-Martínez P, et al. Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients. PLoS ONE. 2012; 7(3):e33264
Abstract: OBJECTIVE Zinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR). METHODS mRNA expression levels of PPARγ, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed. RESULTS The morbidly obese patients with low IR had a higher VAT ZAG expression as compared with the patients with high IR (p = 0.023). In the patients with low IR, the VAT ZAG expression was greater than that in SAT (p = 0.009). ZAG expression correlated between SAT and VAT (r = 0.709, p<0.001). VAT ZAG expression was mainly predicted by insulin, HOMA-IR, plasma adiponectin and expression of adiponectin and ACSS2. SAT ZAG expression was only predicted by expression of ATGL. CONCLUSIONS ZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance. These findings suggest that ZAG may be a useful target in obesity and related disorders, such as diabetes.
Description: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/1158
metadata.dc.relation.publisherversion: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033264
metadata.dc.identifier.doi: 10.1371/journal.pone.0033264
ISSN: 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Reina Sofía
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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