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CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales

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dc.contributor.authorRodriguez-Baño, Jesus
dc.contributor.authorGutierrez-Gutierrez, Belen
dc.contributor.authorPascual, Alvaro
dc.contributor.authoraffiliation[Rodríguez-Baño,J; Gutiérrez-Gutiérrez,B; Pascual,A] Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena and Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain. [Rodríguez-Baño,J; Gutiérrez-Gutiérrez,B] Departamento de Medicina, Universidad de Sevilla, Seville, Spain. [Pascual,A] Departamento de Microbiología, Universidad de Sevilla, Seville, Spain.
dc.contributor.funderThis work was funded by Plan Nacional de I! D!i 2013-2016 and Instituto de Salud Carlos III, Subdireccio´n General de Redes y Centros de Investigacio´n Cooperativa, Ministerio de Economı´a, Industria y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI; RD16/0016/0001), co-financed by European Development Regional Fund ‘A way to achieve Europe’, Operative Program Intelligent Growth 2014-2020.
dc.date.accessioned2022-10-27T08:21:55Z
dc.date.available2022-10-27T08:21:55Z
dc.date.issued2021-02-24
dc.description.abstractCarbapenems are considered the drugs of choice for the treatment of serious infections caused by ceftriaxone-resistant Enterobacterales. However, because of the dramatic increase in carbapenem-resistant organisms worldwide, finding alternatives to carbapenems is a must. The potential options include β-lactam/β-lactamase inhibitor combinations, temocillin, cephamycins and some non-β-lactam drugs. The most controversial is piperacillin/tazobactam; the results of the MERINO trial are challenged because the isolates of patients with worse outcomes were frequently not susceptible to piperacillin/tazobactam when studied by reference methods, and also because the drug was not administered in extended infusion. Other potential options are briefly discussed. We conclude that carbapenems are not necessary for all patients with infections caused by ceftriaxone-resistant Enterobacterales.es_ES
dc.description.versionYeses_ES
dc.identifier.citationRodríguez-Baño J, Gutiérrez-Gutiérrez B, Pascual A. CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales. JAC Antimicrob Resist. 2021 Feb 24;3(1):dlaa112es_ES
dc.identifier.doi10.1093/jacamr/dlaa112es_ES
dc.identifier.essn2632-1823
dc.identifier.pmcPMC8210108
dc.identifier.pmid34223064es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4290
dc.journal.titleJAC-Antimicrobial Resistance
dc.language.isoen
dc.page.number4 p.
dc.provenanceRealizada la curación de contenido 15/04/2025
dc.publisherOxford University Presses_ES
dc.relation.publisherversionhttps://academic.oup.com/jacamr/article/3/1/dlaa112/6146932es_ES
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectCeftriaxonees_ES
dc.subjectCarbapenemses_ES
dc.subjectCephamycinses_ES
dc.subjectLactamses_ES
dc.subjectInfectionses_ES
dc.subjectPiperacillin/tazobactames_ES
dc.subjectPneumoniaes_ES
dc.subject.decsCeftriaxona
dc.subject.decsCarbapenémicos
dc.subject.decsCefamicinas
dc.subject.decsLactamas
dc.subject.decsCombinación piperacilina y tazobactam
dc.subject.decsNeumonía
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins::Cephacetrile::Cefotaxime::Ceftriaxonees_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Carbapenemses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins::Cephamycinses_ES
dc.subject.meshMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross Infection::Pneumonia, Ventilator-Associatedes_ES
dc.subject.meshMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septices_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agentses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosideses_ES
dc.subject.meshMedical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Meningitises_ES
dc.titleCON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacteraleses_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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