Publication: CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales
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Date
2021-02-24
Authors
Rodríguez-Baño, Jesús
Gutiérrez-Gutiérrez, Belén
Pascual, Alvaro
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Publisher
Oxford University Press
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Abstract
Carbapenems are considered the drugs of choice for the treatment of serious infections caused by ceftriaxone-resistant Enterobacterales. However, because of the dramatic increase in carbapenem-resistant organisms worldwide, finding alternatives to carbapenems is a must. The potential options include β-lactam/β-lactamase inhibitor combinations, temocillin, cephamycins and some non-β-lactam drugs. The most controversial is piperacillin/tazobactam; the results of the MERINO trial are challenged because the isolates of patients with worse outcomes were frequently not susceptible to piperacillin/tazobactam when studied by reference methods, and also because the drug was not administered in extended infusion. Other potential options are briefly discussed. We conclude that carbapenems are not necessary for all patients with infections caused by ceftriaxone-resistant Enterobacterales.
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MeSH Terms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins::Cephacetrile::Cefotaxime::Ceftriaxone
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Carbapenems
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins::Cephamycins
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross Infection::Pneumonia, Ventilator-Associated
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides
Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Meningitis
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins::Cephacetrile::Cefotaxime::Ceftriaxone
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Carbapenems
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins::Cephamycins
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross Infection::Pneumonia, Ventilator-Associated
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides
Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Meningitis
DeCS Terms
CIE Terms
Keywords
Ceftriaxone, Carbapenems, Cephamycins, Lactams, Infections, Piperacillin/tazobactam, Pneumonia, Ceftriaxona, Carbapenémicos, Cefamicinas, Lactamas, Combinación piperacilina y tazobactam, Neumonía
Citation
Rodríguez-Baño J, Gutiérrez-Gutiérrez B, Pascual A. CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales. JAC Antimicrob Resist. 2021 Feb 24;3(1):dlaa112