Publication:
Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial.

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Date

2018-05-16

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Sanchez-Rodriguez, Estefania
Lima-Cabello, Elena
Biel-Glesson, Sara
Fernandez-Navarro, Jose R
Calleja, Miguel A
Roca, Maria
Espejo-Calvo, Juan A
Gil-Extremera, Blas
Soria-Florido, Maria
de la Torre, Rafael

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Abstract

The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).

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MeSH Terms

Adult
Biomarkers
Cholesterol, HDL
Cross-Over Studies
Dietary Supplements
Double-Blind Method
Endothelin-1
Endothelium, Vascular
Energy Intake
Female
Food, Fortified
Humans
Male
Metabolic Syndrome
Middle Aged
Olive Oil
Phenols
Phytochemicals
Triterpenes

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Keywords

cardiovascular diseases, endothelial function, maslinic acid, metabolic syndrome, oleanolic acid, olive oil, olive oil polyphenols, phenolic compounds, triterpenes, virgin olive oil

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