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Validation of a prognostic score for hidden cancer in unprovoked venous thromboembolism.

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Date

2018-03-20

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Jara-Palomares, Luis
Otero, Remedios
Jimenez, David
Praena-Fernandez, Juan Manuel
Font, Carme
Falga, Conxita
Soler, Silvia
Riesco, David
Verhamme, Peter
Monreal, Manuel

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The usefulness of a diagnostic workup for occult cancer in patients with venous thromboembolism (VTE) is controversial. We used the RIETE (Registro Informatizado Enfermedad Trombo Embólica) database to perform a nested case-control study to validate a prognostic score that identifies patients with unprovoked VTE at increased risk for cancer. We dichotomized patients as having low- (≤2 points) or high (≥3 points) risk for cancer, and tried to validate the score at 12 and 24 months. From January 2014 to October 2016, 11,695 VTE patients were recruited. Of these, 1,360 with unprovoked VTE (11.6%) were eligible for the study. At 12 months, 52 patients (3.8%; 95%CI: 2.9-5%) were diagnosed with cancer. Among 905 patients (67%) scoring ≤2 points, 22 (2.4%) had cancer. Among 455 scoring ≥3 points, 30 (6.6%) had cancer (hazard ratio 2.8; 95%CI 1.6-5; p

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Adult
Aged
Aged, 80 and over
Case-Control Studies
Databases, Factual
Diagnosis, Differential
Early Detection of Cancer
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasms
Neoplasms, Unknown Primary
Prognosis
Registries
Research Design
Risk Factors
Venous Thromboembolism

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