RT Journal Article
T1 Validation of a prognostic score for hidden cancer in unprovoked venous thromboembolism.
A1 Jara-Palomares, Luis
A1 Otero, Remedios
A1 Jimenez, David
A1 Praena-Fernandez, Juan Manuel
A1 Font, Carme
A1 Falga, Conxita
A1 Soler, Silvia
A1 Riesco, David
A1 Verhamme, Peter
A1 Monreal, Manuel
K1 Venous thromboembolism
K1 Lung and intrathoracic tumors
K1 Cancers and neoplasms
K1 Cancer detection and diagnosis
K1 Breast cancer
K1 Cancer risk factors
K1 Colorectal cancer
K1 Prostate cancer
AB The usefulness of a diagnostic workup for occult cancer in patients with venous thromboembolism (VTE) is controversial. We used the RIETE (Registro Informatizado Enfermedad Trombo Embólica) database to perform a nested case-control study to validate a prognostic score that identifies patients with unprovoked VTE at increased risk for cancer. We dichotomized patients as having low- (≤2 points) or high (≥3 points) risk for cancer, and tried to validate the score at 12 and 24 months. From January 2014 to October 2016, 11,695 VTE patients were recruited. Of these, 1,360 with unprovoked VTE (11.6%) were eligible for the study. At 12 months, 52 patients (3.8%; 95%CI: 2.9-5%) were diagnosed with cancer. Among 905 patients (67%) scoring ≤2 points, 22 (2.4%) had cancer. Among 455 scoring ≥3 points, 30 (6.6%) had cancer (hazard ratio 2.8; 95%CI 1.6-5; p<0.01). C-statistic was 0.63 (95%CI 0.55-0.71). At 24 months, 58 patients (4.3%; 95%CI: 3.3-5.5%) were diagnosed with cancer. Among 905 patients scoring ≤2 points, 26 (2.9%) had cancer. Among 455 patients scoring ≥3 points, 32 (7%) had cancer (hazard ratio 2.6; 95%CI 1.5-4.3; p<0.01). C-statistic was 0.61 (95%CI, 0.54-0.69). We validated our prognostic score at 12 and 24 months, although prospective cohort validation is needed. This may help to identify patients for whom more extensive screening workup may be required.
PB Public Library of Science
YR 2018
FD 2018-03-20
LK http://hdl.handle.net/10668/12255
UL http://hdl.handle.net/10668/12255
LA en
NO Jara-Palomares L, Otero R, Jimenez D, Praena-Fernandez JM, Font C, Falga C, et al. Validation of a prognostic score for hidden cancer in unprovoked venous thromboembolism. PLoS One. 2018 Mar 20;13(3):e0194673.
DS RISalud
RD Aug 12, 2025