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MitoBlue as a tool to analyze the mitochondria-lysosome communication

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dc.contributor.authorSánchez, Mateo I.
dc.contributor.authorVida, Yolanda
dc.contributor.authorPérez-Inestrosa, Ezequiel
dc.contributor.authorMascareñas, José L.
dc.contributor.authorVázquez, M. Eugenio
dc.contributor.authorSugiura, Ayumu
dc.contributor.authorMartínez-Costas, José
dc.contributor.authoraffiliation[Sánchez,MI; Mascareñas,JL; Vázquez,ME] Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago de Compostela, Spain. [Sugiura,A] Montreal Neurological Institute, McGill University, Montreal, QC, Canada. [Sugiura,A] Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada. [Vida,Y; Pérez-Inestrosa,E] Centro Andaluz de Nanomedicina y Biotecnología-BIONAND. Campanillas, Málaga, Spain. [Martínez-Costas,J] Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Bioquímica y Biología Molecular, Universidade de Santiago de Compostela, Santiago de, Compostela, Spain. [Vida,Y; Pérez-Inestrosa,E] Universidad de Málaga-IBIMA, Departamento de Química Orgánica, Málaga, Spain.
dc.contributor.funderThe support was given by the Spanish grants BFU2013-43513-R, SAF2016-76689-R, CTQ2015-70698-R, RTI2018-099877-B-I00, CTQ2013-49317-EXP, CTQ2013-41339-P, CTQ2016-75870-P, CTQ2015-71896-REDT (Red de Fotoquímica Biológica) and Instituto de Salud Carlos III (ISCIII; RETIC ARADYAL D16/0006/0012), Junta de Andalucía (PI0250-2016 and UMA18-FEDERJA-007), Orfeo-cinqa network CTQ2016-81797-REDC; the Xunta de Galicia (2015-CP082, ED431C 2017/19, Centro Singular de investigación de Galicia accreditation 2019–2022, ED431G 2019/03), the European Union (European Regional Development Fund - ERDF), and the European Research Council (Advanced Grant No. 340055) are gratefully acknowledged. M.E.V. also acknowledges the support provided by the Fundación AECC IDEAS197VAZQ grant). A.S. was supported by the Uehara Memorial Foundation and a JSPS Postdoctoral Fellowship for Research Abroad.
dc.date.accessioned2022-07-29T11:52:20Z
dc.date.available2022-07-29T11:52:20Z
dc.date.issued2020-02-26
dc.description.abstractMitoBlue is a fluorescent bisamidine that can be used to easily monitor the changes in mitochondrial degradation processes in different cells and cellular conditions. MitoBlue staining pattern is exceptional among mitochondrial dyes and recombinant fluorescent probes, allowing the dynamic study of mitochondrial recycling in a variety of situations in living cells. MitoBlue is a unique tool for the study of these processes that will allow the detailed characterization of communication between mitochondria and lysosomes.es_ES
dc.description.versionYeses_ES
dc.identifier.citationSánchez MI, Vida Y, Pérez-Inestrosa E, Mascareñas JL, Vázquez ME, Sugiura A, et al. MitoBlue as a tool to analyze the mitochondria-lysosome communication. Sci Rep. 2020 Feb 26;10(1):3528es_ES
dc.identifier.doi10.1038/s41598-020-60573-7es_ES
dc.identifier.essn2045-2322
dc.identifier.pmcPMC7044336
dc.identifier.pmid32103132es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3856
dc.journal.titleScientific Reports
dc.language.isoen
dc.page.number12 p.
dc.publisherSpringer Naturees_ES
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-020-60573-7es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMitochondrial degradationes_ES
dc.subjectLysosomees_ES
dc.subjectMicroscopyes_ES
dc.subjectMitochondriaes_ES
dc.subjectProteinses_ES
dc.subjectQuality controles_ES
dc.subjectMitofagiaes_ES
dc.subjectLisosomases_ES
dc.subjectMicroscopíaes_ES
dc.subjectMitocondriases_ES
dc.subjectProteínases_ES
dc.subjectControl de calidades_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::2-Naphthylaminees_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amidineses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Embryonic Structures::Embryo, Nonmammalian::Chick Embryoes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Fibroblastses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Cytoplasmic Vesicles::Lysosomeses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Microscopy::Microscopy, Fluorescencees_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondriaes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Laboratory Chemicals::Indicators and Reagents::Luminescent Agents::Fluorescent Dyeses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Histological Techniques::Histocytological Preparation Techniques::Staining and Labelinges_ES
dc.titleMitoBlue as a tool to analyze the mitochondria-lysosome communicationes_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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