Publication:
The emergent role of mitochondrial RNA modifications in metabolic alterations.

No Thumbnail Available

Date

2022-07-25

Authors

Boughanem, Hatim
Böttcher, Yvonne
Tomé-Carneiro, João
López de Las Hazas, María-Carmen
Dávalos, Alberto
Cayir, Akin
Macias-González, Manuel

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial evidence indicates that they play a critical role in accurate protein synthesis. Recent evidence supported those modifications in mitochondrial RNAs also have crucial implications in mitochondrial-related diseases. In the light of current knowledge about the involvement, the association between mitochondrial RNA modifications and diseases arises from studies focusing on mutations in both mitochondrial and nuclear DNA genes encoding enzymes involved in such modifications. Here, we review the current evidence available for mitochondrial RNA modifications and their role in metabolic disorders, and we also explore the possibility of using them as promising targets for prevention and early detection. Finally, we discuss future directions of mitochondrial epitranscriptomics in these metabolic alterations, and how these RNA modifications may offer a new diagnostic and theragnostic avenue for preventive purposes. This article is categorized under: RNA Processing > RNA Editing and Modification.

Description

MeSH Terms

Humans
RNA, Mitochondrial
RNA
Mitochondrial Diseases
Mitochondria
RNA Processing, Post-Transcriptional

DeCS Terms

CIE Terms

Keywords

RNA modifications, epitranscriptomics, metabolic alterations, metabolism, mitochondria

Citation