RT Journal Article
T1 The emergent role of mitochondrial RNA modifications in metabolic alterations.
A1 Boughanem, Hatim
A1 Böttcher, Yvonne
A1 Tomé-Carneiro, João
A1 López de Las Hazas, María-Carmen
A1 Dávalos, Alberto
A1 Cayir, Akin
A1 Macias-González, Manuel
K1 RNA modifications
K1 epitranscriptomics
K1 metabolic alterations
K1 metabolism
K1 mitochondria
AB Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial evidence indicates that they play a critical role in accurate protein synthesis. Recent evidence supported those modifications in mitochondrial RNAs also have crucial implications in mitochondrial-related diseases. In the light of current knowledge about the involvement, the association between mitochondrial RNA modifications and diseases arises from studies focusing on mutations in both mitochondrial and nuclear DNA genes encoding enzymes involved in such modifications. Here, we review the current evidence available for mitochondrial RNA modifications and their role in metabolic disorders, and we also explore the possibility of using them as promising targets for prevention and early detection. Finally, we discuss future directions of mitochondrial epitranscriptomics in these metabolic alterations, and how these RNA modifications may offer a new diagnostic and theragnostic avenue for preventive purposes. This article is categorized under: RNA Processing > RNA Editing and Modification.
YR 2022
FD 2022-07-25
LK http://hdl.handle.net/10668/22594
UL http://hdl.handle.net/10668/22594
LA en
DS RISalud
RD Apr 17, 2025