Publication: Protease inhibitor monotherapy is effective in controlling human immunodeficiency virus 1 shedding in the male genital tract
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Date
2016-01-01
Authors
Torres-Cornejo, A.
BenMarzouk-Hidalgo, O. J.
Viciana, P.
Sanchez, B.
Lopez-Ruz, M. A.
Lopez-Cortes, L. F.
Gutierrez-Valencia, A.
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Elsevier sci ltd
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Abstract
Cross-sectional study comparing seminal human immunodeficiency virus type 1 (HIV-1) shedding in patients receiving boosted protease inhibitor monotherapy (mtPI/rtv) (n = 66) versus triple therapy (TT) (n = 61). Seminal HIV-1 shedding rates in patients with undetectable plasma HIV-RNA were 16.0% on mtPI/rtv compared with 28.6% on TT (p 0.173). Aviraemic status and time on viral suppression were independently associated with lack of seminal HIV-1 shedding. During TT, non PI/rtv-based regimens were associated with a better control of HIV infection in semen despite similar time on viral suppression. The use of mtPI/rtv in well-controlled patients is not associated with increased seminal HIV excretion compared with TT. (C)2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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Human immunodeficiency virus 1 infection, human immunodeficiency virus 1 treatment, male genital tract, protease inhibitor monotherapy, triple therapy, Viral load, Blood-plasma, Hiv-1 rna, Semen, Lopinavir/ritonavir, Men, Ritonavir