Publication:
Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project.

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2019-06-14

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Bassetti, Matteo
Giacobbe, Daniele R
Vena, Antonio
Trucchi, Cecilia
Ansaldi, Filippo
Antonelli, Massimo
Adamkova, Vaclava
Alicino, Cristiano
Almyroudi, Maria-Panagiota
Atchade, Enora

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Abstract

The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p  The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

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Aged
Candidiasis, Invasive
Cross Infection
Europe
Female
Humans
Incidence
Intensive Care Units
Male
Middle Aged
Outcome Assessment, Health Care
Retrospective Studies
Risk Factors

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Keywords

Abdominal candidiasis, Candida, Candidemia, Candidiasis, ICU, Incidence

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