Publication:
Epidermal Barrier Function and Skin Homeostasis in Atopic Dermatitis: The Impact of Age.

Loading...
Thumbnail Image

Date

2022-01-17

Authors

Montero-Vilchez, Trinidad
Cuenca-Barrales, Carlos
Rodriguez-Pozo, Juan-Angel
Diaz-Calvillo, Pablo
Tercedor-Sanchez, Jesús
Martinez-Lopez, Antonio
Molina-Leyva, Alejandro
Arias-Santiago, Salvador

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Skin is damaged in atopic dermatitis (AD) patients. Age is also believed to have a negative effect on epidermal barrier function. The aim of this study was to investigate skin barrier function changes with age in AD patients. A cross-sectional study was conducted including 162 participants, 81 AD patients and 81 healthy volunteers. Skin barrier function parameters, such as transepidermal water loss (TEWL), erythema, temperature, stratum corneum hydration (SCH), pH, and elasticity, were evaluated. Healthy volunteers were evaluated on the volar forearm. AD patients were measured on two regions: on an eczematous lesion on the volar forearm and on a non-involved area 5 cm from the affected area. TEWL was lower on healthy skin than uninvolved AD skin (9.98 vs. 25.51 g·m-2·h-1, p

Description

MeSH Terms

DeCS Terms

CIE Terms

Keywords

aging, atopic dermatitis, skin barrier, stratum corneum

Citation