RT Journal Article
T1 Epidermal Barrier Function and Skin Homeostasis in Atopic Dermatitis: The Impact of Age.
A1 Montero-Vilchez, Trinidad
A1 Cuenca-Barrales, Carlos
A1 Rodriguez-Pozo, Juan-Angel
A1 Diaz-Calvillo, Pablo
A1 Tercedor-Sanchez, Jesús
A1 Martinez-Lopez, Antonio
A1 Molina-Leyva, Alejandro
A1 Arias-Santiago, Salvador
K1 aging
K1 atopic dermatitis
K1 skin barrier
K1 stratum corneum
AB Skin is damaged in atopic dermatitis (AD) patients. Age is also believed to have a negative effect on epidermal barrier function. The aim of this study was to investigate skin barrier function changes with age in AD patients. A cross-sectional study was conducted including 162 participants, 81 AD patients and 81 healthy volunteers. Skin barrier function parameters, such as transepidermal water loss (TEWL), erythema, temperature, stratum corneum hydration (SCH), pH, and elasticity, were evaluated. Healthy volunteers were evaluated on the volar forearm. AD patients were measured on two regions: on an eczematous lesion on the volar forearm and on a non-involved area 5 cm from the affected area. TEWL was lower on healthy skin than uninvolved AD skin (9.98 vs. 25.51 g·m-2·h-1, p
SN 2075-1729
YR 2022
FD 2022-01-17
LK http://hdl.handle.net/10668/21394
UL http://hdl.handle.net/10668/21394
LA en
DS RISalud
RD Apr 6, 2025