Publication:
MICA*A4 protects against ulcerative colitis, whereas MICA*A5.1 is associated with abscess formation and age of onset.

No Thumbnail Available

Date

2016-04-05

Authors

Martinez-Chamorro, A
Moreno, A
Gómez-García, M
Cabello, M J
Martin, J
Lopez-Nevot, M Á

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Ulcerative colitis (UC) is one of the two major forms of inflammatory bowel disease, the aetiology of which remains unknown. Several studies have demonstrated the genetic basis of disease, identifying more than 130 susceptibility loci. The major histocompatibility complex class I chain-related gene A (MICA) is a useful candidate to be involved in UC pathogenesis, because it could be important in recognizing the integrity of the epithelial cell and its response to stress. The aim of this study was to analyse the relationship between polymorphisms in the transmembrane domain of MICA and susceptibility to develop UC. A total of 340 patients with UC and 636 healthy controls were genotyped for MICA transmembrane polymorphism using a polymerase chain reaction (PCR) combined with fluorescent technology. Different MICA alleles were determined depending on the PCR product size. The allele MICA*A4 was less frequent in patients than in controls (P = 0·003; OR = 0·643), and this protective role is higher when it forms haplotype with B*27 (P = 0·002; OR = 0·294). The haplotype HLA-B*52/MICA*A6 was also associated with UC [P = 0·001; odds ratio (OR) = 2·914]. No other alleles, genotypes or haplotypes were related with UC risk. Moreover, MICA*A5.1 is associated independently with abscesses (P = 0·002; OR = 3·096) and its frequency is lower in patients diagnosed between ages 17 and 40 years (P = 0·007; OR = 0·633), meaning an extreme age on onset. No association with location, extra-intestinal manifestations or need for surgery was found.

Description

MeSH Terms

Abscess
Adult
Age of Onset
Alleles
Amino Acid Sequence
Case-Control Studies
Colitis, Ulcerative
Female
Gene Expression
Gene Frequency
Genetic Predisposition to Disease
HLA-B27 Antigen
HLA-B52 Antigen
Haplotypes
Histocompatibility Antigens Class I
Humans
Male
Middle Aged
Models, Molecular
Odds Ratio
Polymorphism, Genetic
Protein Domains
Protein Isoforms
Sequence Alignment

DeCS Terms

CIE Terms

Keywords

MHC, autoimmunity, cell surface molecules, inflammation, molecular biology

Citation