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Value of [18F]FDG-PET/CT and CA125, serum levels and kinetic parameters, in early detection of ovarian cancer recurrence: Influence of histological subtypes and tumor stages.

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2018

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Palomar Muñoz, Azahara
Cordero García, José Manuel
Talavera Rubio, Mª Del Prado
García Vicente, Ana Mª
Pena Pardo, Francisco José
Jiménez Londoño, Germán Andrés
Soriano Castrejón, Ángel
Aranda Aguilar, Enrique

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To assess the diagnostic accuracy of CA125, its kinetic values and positron emission tomography/computed tomography with 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG-PET/CT), in relation with tumor characteristics for suspected recurrence of ovarian cancer. To evaluate the performance of CA125-related parameters as a selection criteria to perform a [F]FDG-PET/CT.A retrospective analysis of 69 [F]FDG-PET/CT for suspected recurrence of ovarian cancer was performed. All patients had 2 measurements of CA125, before PET/CT, to calculate kinetic values, as CA125vel (CA125vel = [CA125a - CA125b]/time) and CA125dt (CA125dt = [log2 × time]/[logCA125a - CA125b]). Maximum standard uptake value (SUVmax) was calculated. The diagnostic accuracy was calculated for all the variables and the optimal cut-off value of each of them by the receiver-operating characteristics (ROC) analysis. All the tests were compared with tumor characteristics and clinical-radiological evolution during follow-up of at least 6 months.Fifty-five cases were diagnosed of recurrence (11 with CA125 

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Aged
Biomarkers, Tumor
CA-125 Antigen
Early Detection of Cancer
Female
Fluorodeoxyglucose F18
Humans
Middle Aged
Neoplasm Recurrence, Local
Ovarian Neoplasms
Positron Emission Tomography Computed Tomography
ROC Curve
Retrospective Studies

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