Publication: Value of [18F]FDG-PET/CT and CA125, serum levels and kinetic parameters, in early detection of ovarian cancer recurrence: Influence of histological subtypes and tumor stages.
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Identifiers
Date
2018
Authors
Palomar Muñoz, Azahara
Cordero García, José Manuel
Talavera Rubio, Mª Del Prado
García Vicente, Ana Mª
Pena Pardo, Francisco José
Jiménez Londoño, Germán Andrés
Soriano Castrejón, Ángel
Aranda Aguilar, Enrique
Advisors
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Abstract
To assess the diagnostic accuracy of CA125, its kinetic values and positron emission tomography/computed tomography with 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG-PET/CT), in relation with tumor characteristics for suspected recurrence of ovarian cancer. To evaluate the performance of CA125-related parameters as a selection criteria to perform a [F]FDG-PET/CT.A retrospective analysis of 69 [F]FDG-PET/CT for suspected recurrence of ovarian cancer was performed. All patients had 2 measurements of CA125, before PET/CT, to calculate kinetic values, as CA125vel (CA125vel = [CA125a - CA125b]/time) and CA125dt (CA125dt = [log2 × time]/[logCA125a - CA125b]). Maximum standard uptake value (SUVmax) was calculated. The diagnostic accuracy was calculated for all the variables and the optimal cut-off value of each of them by the receiver-operating characteristics (ROC) analysis. All the tests were compared with tumor characteristics and clinical-radiological evolution during follow-up of at least 6 months.Fifty-five cases were diagnosed of recurrence (11 with CA125
Description
MeSH Terms
Aged
Biomarkers, Tumor
CA-125 Antigen
Early Detection of Cancer
Female
Fluorodeoxyglucose F18
Humans
Middle Aged
Neoplasm Recurrence, Local
Ovarian Neoplasms
Positron Emission Tomography Computed Tomography
ROC Curve
Retrospective Studies
Biomarkers, Tumor
CA-125 Antigen
Early Detection of Cancer
Female
Fluorodeoxyglucose F18
Humans
Middle Aged
Neoplasm Recurrence, Local
Ovarian Neoplasms
Positron Emission Tomography Computed Tomography
ROC Curve
Retrospective Studies