Publication:
Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk.

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Date

2022-09-12

Authors

Rubin-Garcia, Maria
Vitelli-Storelli, Facundo
Alvarez-Alvarez, Laura
Martinez-Gonzalez, Miguel Angel
Salas-Salvado, Jordi
Corella, Dolores
Hernaez, Alvaro
Martinez, J Alfredo
Alonso-Gomez, Angel M
Wärnberg, Julia

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Wiley-Blackwell Publishing
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Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.

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MeSH Terms

Male
Female
Humans
Hyperuricemia
Uric Acid
Cross-Sectional Studies
Polyphenols
Coumaric Acids
Cardiovascular Diseases
Risk Factors
Heart Disease Risk Factors
Hydroxybenzoates

DeCS Terms

Enfermedades cardiovasculares
Factores de riesgo de enfermedad cardiaca
Hidroxibenzoatos
Hiperuricemia
Polifenoles
Ácido úrico
Ácidos cumáricos

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Keywords

Hyperuricemia, Polyphenols, Uric acid

Citation

Rubín-García M, Vitelli-Storelli F, Álvarez-Álvarez L, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk. J Am Heart Assoc. 2022 Oct 18;11(20):e026053