RT Journal Article
T1 Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk.
A1 Rubin-Garcia, Maria
A1 Vitelli-Storelli, Facundo
A1 Alvarez-Alvarez, Laura
A1 Martinez-Gonzalez, Miguel Angel
A1 Salas-Salvado, Jordi
A1 Corella, Dolores
A1 Hernaez, Alvaro
A1 Martinez, J Alfredo
A1 Alonso-Gomez, Angel M
A1 Wärnberg, Julia
A1 Vioque, Jesus
A1 Romaguera, Dora
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Tinahones, Francisco J
A1 Serra-Majem, Luis I
A1 Cano-Ibañez, Naomi
A1 Tur, Josep A
A1 Marcos-Delgado, Alba
A1 Tresserra-Rimbau, Anna
A1 Pinto, Xavier
A1 Delgado-Rodriguez, Miguel
A1 Matia-Martin, Pilar
A1 Vidal, Josep
A1 Vazquez, Clotilde
A1 Daimiel, Lidia
A1 Ros, Emili
A1 Vazquez-Ruiz, Zenaida
A1 Babio, Nancy
A1 Barragan, Rocio
A1 Castañer-Niño, Olga
A1 Razquin, Cristina
A1 Tojal-Sierra, Lucas
A1 Gomez-Gracia, Enrique
A1 Gonzalez-Palacios, Sandra
A1 Morey, Marga
A1 Garcia-Rios, Antonio
A1 Castro-Barquero, Sara
A1 Bernal-Lopez, Maria Rosa
A1 Santos-Lozano, Jose Manuel
A1 Ruiz-Canela, Miguel
A1 Castro-Salomo, Antoni
A1 Pascual-Castello, Eva Cristina
A1 Moldon, Veronica
A1 Bullon-Vela, Vanessa
A1 Sorto-Sanchez, Carolina
A1 Cenoz-Osinaga, Juan Carlos
A1 Gutierrez, Liliana
A1 Mengual, Maira
A1 Lamuela-Raventos, Rosa Maria
A1 Martin-Sanchez, Vicente
K1 Hyperuricemia
K1 Polyphenols
K1 Uric acid
AB Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross-sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, -0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, -0.27 to -0.06]) and hydroxycinnamic acids (β coefficient, -0.19 [95% CI, -0.3 to -0.09]), alkylmethoxyphenols (β coefficient, -0.2 [95% CI, -0.31 to -0.1]), and methoxyphenols (β coefficient, -0.24 [95% CI, -0.34 to -0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.82 [95% CI, 0.71-0.95]; PR, 0.80 [95% CI, 0.70-0.92]; and PR, 0.79 [95% CI, 0.69-0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02-0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.
PB Wiley-Blackwell Publishing
YR 2022
FD 2022-09-12
LK http://hdl.handle.net/10668/20201
UL http://hdl.handle.net/10668/20201
LA en
NO Rubín-García M, Vitelli-Storelli F, Álvarez-Álvarez L, Martínez-González MÁ, Salas-Salvadó J, Corella D, et al. Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross-Sectional Analysis in a Population at High Cardiovascular Risk. J Am Heart Assoc. 2022 Oct 18;11(20):e026053
DS RISalud
RD Apr 18, 2025