Publication: Risk factors in pediatric T-cell acute lymphoblastic leukemia: a collaborative study of the biological committee of the leukemia group of the Spanish Hematology and Oncology Pediatric Society
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Identifiers
Date
2016-06
Authors
Vega-García, N
Torrebadell, M
Jiménez-Velasco, A
Ortega, M
Abad, L
Pratcorona, M
Muñoz, L
Malatesta, R
Calvente, L
Català, A
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Ferrata Storti Foundation
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Abstract
Background: Useful biomarkers for risk stratification in pediatric T-ALL are
still needed. Several biological variables have been proposed as new prognostic
biomarkers, including NOTCH1, FBXW7, PTEN & RAS mutations,
expression of myeloid antigens and presence of copy number alterations
(CNAs) of certain genes, but published results are controversial.
Aims: To analyze the prognostic impact of mutations, CNAs and myeloid antigens
expression in a series of 56 pediatric T-ALL patients.
Description
MeSH Terms
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biomarkers
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cell Cycle Proteins
Medical Subject Headings::Named Groups::Persons::Age Groups::Child
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::F-Box Proteins
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
Medical Subject Headings::Diseases::Immune System Diseases::Immunoproliferative Disorders::Lymphoproliferative Disorders::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma::Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Ligases::Ubiquitin-Protein Ligase Complexes::Ubiquitin-Protein Ligases
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cell Cycle Proteins
Medical Subject Headings::Named Groups::Persons::Age Groups::Child
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::F-Box Proteins
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
Medical Subject Headings::Diseases::Immune System Diseases::Immunoproliferative Disorders::Lymphoproliferative Disorders::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma::Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Ligases::Ubiquitin-Protein Ligase Complexes::Ubiquitin-Protein Ligases
DeCS Terms
CIE Terms
Keywords
Biomarcadores, Proteínas del ciclo celular, Niño, Proteínas F-box, Humanos, Mutación, Leucemia-linfoma linfoblástico de células T precursoras, Ubicuitina-proteína ligasas
Citation
Vega-García N, Torrebadell M, Jiménez-Velasco A; Ortega M, Abad L, Pratcorona M, et al. Risk factors in pediatric T-cell acute lymphoblastic leukemia: a collaborative study of the biological committee of the leukemia group of the Spanish Hematology and Oncology Pediatric Society. Haematologica. 2016; 101 (s1) E870.