Publication:
Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort).

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Date

2022-06-13

Authors

Peluso, Marco
Munnia, Armelle
Russo, Valentina
Galli, Andrea
Pala, Valeria
Schouw, Yvonne T van der
Schulze, Matthias B
Weiderpass, Elisabete
Tumino, Rosario
Saieva, Calogero

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MDPI AG
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Abstract

Epidemiologic studies have indicated that cruciferous vegetables can influence the cancer risk; therefore, we examined with a cross-sectional approach the correlation between the frequent consumption of the total cruciferous vegetables and the formation of bulky DNA damage, a biomarker of carcinogen exposure and cancer risk, in the Gen-Air study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. DNA damage measurements were performed in the peripheral blood of 696 of those apparently healthy without cancer controls, including 379 never-smokers and 317 former smokers from seven European countries by the 32P-postlabeling assay. In the Gen-Air controls, the median intake of cruciferous vegetables was 6.16 (IQR 1.16−13.66) g/day, ranging from 0.37 (IQR 0−6.00) g/day in Spain to 11.34 (IQR 6.02−16.07) g/day in the UK. Based on this information, participants were grouped into: (a) high consumers (>20 g/day), (b) medium consumers (3−20 g/day) and (c) low consumers (20 g/day), (b) medium consumers (3−20 g/day) and (c) low consumers (

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MeSH Terms

Brassicaceae
DNA Damage
Diet
Dietary Fiber
Humans
Neoplasms
Non-Smokers
Prospective Studies
Smokers
Smoking
Vegetables

DeCS Terms

Brassicaceae
Daño del ADN
Dieta
Estudios Prospectivos
Fibras de la dieta
Fumadores
Fumar
Humanos
Neoplasias
No fumadores
Verduras

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Keywords

B(a)P-adducts, DNA damage, EPIC, bulky oxidative lesions, cruciferous vegetables, diet

Citation

Peluso M, Munnia A, Russo V, Galli A, Pala V, Schouw YTV, et al. Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort). Nutrients. 2022 Jun 15;14(12):2477.