Publication:
Sex Differences in the Gut Microbiota as Potential Determinants of Gender Predisposition to Disease.

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Date

2019-02-13

Authors

Santos-Marcos, Jose A
Haro, Carmen
Vega-Rojas, Ana
Alcala-Diaz, Juan F
Molina-Abril, Helena
Leon-Acuña, Ana
Lopez-Moreno, Javier
Landa, Blanca B
Tena-Sempere, Manuel
Perez-Martinez, Pablo

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Wiley
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Abstract

Dysbiosis of gut microbiota is involved in metabolic syndrome (MetS) development, which has a different incidence between men (M) and women (W). The differences in gut microbiota in MetS patients are explored according to gender, and whether consuming two healthy diets, Mediterranean (MED) and low-fat (LF), may, over time, differentially shape the gut microbiota dysbiosis according to gender is evaluated. All the women from the CORDIOPREV study whose feces samples were available and a similar number of men, matched by the main metabolic variables (N = 246, 123 women and 123 men), and categorized according to the presence or not of MetS are included. Gut microbiota is analyzed at baseline and after 3 years of dietary intervention. Higher abundance of Collinsella, Alistipes, Anaerotruncus, and Phascolarctobacterium genera is observed in MetS-W than in MetS-M, whereas the abundance of Faecalibacterium and Prevotella genera is higher in MetS-M than in MetS-W. Moreover, higher levels of Desulfovibrio, Roseburia, and Holdemania are observed in men than in women after the consumption of the LF diet. The results suggest the potential involvement of differences in gut microbiota in the unequal incidence of metabolic diseases between genders, and a sex-dependent effect on shaping the gut microbiota according to diet.

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MeSH Terms

Cholesterol, HDL
Diet, fat-restricted
Diet, mediterranean
Disease susceptibility
Feces
Female
Gastrointestinal microbiome
Humans
Male
Metabolic syndrome
Middle aged
Sex factors

DeCS Terms

Dieta mediterránea
Dieta con restricción de grasas
Factores sexuales
Microbioma gastrointestinal
Susceptibilidad a enfermedades
Síndrome metabólico

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Keywords

Dysbiosis, Gut microbiota,metabolic diseases, Obesity, Sexual dimorphism

Citation

Santos-Marcos JA, Haro C, Vega-Rojas A, Alcala-Diaz JF, Molina-Abril H, Leon-Acuña A, et al. Sex Differences in the Gut Microbiota as Potential Determinants of Gender Predisposition to Disease. Mol Nutr Food Res. 2019 Apr;63(7):e1800870