RT Journal Article
T1 Sex Differences in the Gut Microbiota as Potential Determinants of Gender Predisposition to Disease.
A1 Santos-Marcos, Jose A
A1 Haro, Carmen
A1 Vega-Rojas, Ana
A1 Alcala-Diaz, Juan F
A1 Molina-Abril, Helena
A1 Leon-Acuña, Ana
A1 Lopez-Moreno, Javier
A1 Landa, Blanca B
A1 Tena-Sempere, Manuel
A1 Perez-Martinez, Pablo
A1 Lopez-Miranda, Jose
A1 Perez-Jimenez, Francisco
A1 Camargo, Antonio
K1 Dysbiosis
K1 Gut microbiota,metabolic diseases
K1 Obesity
K1 Sexual dimorphism
AB Dysbiosis of gut microbiota is involved in metabolic syndrome (MetS) development, which has a different incidence between men (M) and women (W). The differences in gut microbiota in MetS patients are explored according to gender, and whether consuming two healthy diets, Mediterranean (MED) and low-fat (LF), may, over time, differentially shape the gut microbiota dysbiosis according to gender is evaluated. All the women from the CORDIOPREV study whose feces samples were available and a similar number of men, matched by the main metabolic variables (N = 246, 123 women and 123 men), and categorized according to the presence or not of MetS are included. Gut microbiota is analyzed at baseline and after 3 years of dietary intervention. Higher abundance of Collinsella, Alistipes, Anaerotruncus, and Phascolarctobacterium genera is observed in MetS-W than in MetS-M, whereas the abundance of Faecalibacterium and Prevotella genera is higher in MetS-M than in MetS-W. Moreover, higher levels of Desulfovibrio, Roseburia, and Holdemania are observed in men than in women after the consumption of the LF diet. The results suggest the potential involvement of differences in gut microbiota in the unequal incidence of metabolic diseases between genders, and a sex-dependent effect on shaping the gut microbiota according to diet.
PB Wiley
YR 2019
FD 2019-02-13
LK http://hdl.handle.net/10668/13416
UL http://hdl.handle.net/10668/13416
LA en
NO Santos-Marcos JA, Haro C, Vega-Rojas A, Alcala-Diaz JF, Molina-Abril H, Leon-Acuña A, et al. Sex Differences in the Gut Microbiota as Potential Determinants of Gender Predisposition to Disease. Mol Nutr Food Res. 2019 Apr;63(7):e1800870
DS RISalud
RD Apr 4, 2025