Publication: FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) in a patient with Crohn's disease on anti-TNF treatment.
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Identifiers
Date
2021
Authors
Cabezudo-Garcia, P
Vidal-Denis, M
Ciano-Petersen, N L
Irigoyen-Oyarzabal, M V
Serrano-Castro, P J
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
The FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) were first described by Ogawa et al. in 2017 as a distinctive clinical-radiological syndrome from other anti-MOG antibody-associated demyelination syndromes, often with a more indolent course. The most frequent clinical manifestations of this syndrome are seizures, headache, fever, and focal cortical deficits congruent with the localization of unilateral cortical FLAIR hyperintense lesions, although bi-hemispheric involvement is not uncommon. The etiology and risk factors for developing the syndrome remain unknown. Some cases have been associated with concomitant anti-NMDAR antibodies, but the association of anti-MOG-related disorders with other autoimmune diseases seems rare. Recently, a case of FLAMES in a patient with inflammatory bowel disease (ulcerative colitis) on TNF inhibitor therapy has been reported.
Description
MeSH Terms
Demyelinating Diseases
Inflammatory Bowel Diseases
Colitis, Ulcerative
Autoimmune Diseases
Inflammatory Bowel Diseases
Colitis, Ulcerative
Autoimmune Diseases
DeCS Terms
Encefalitis
Enfermedades Inflamatorias del Intestino
Fiebre
Colitis Ulcerosa
Enfermedades Desmielinizantes
Inhibidores del Factor de Necrosis Tumoral
Enfermedades Inflamatorias del Intestino
Fiebre
Colitis Ulcerosa
Enfermedades Desmielinizantes
Inhibidores del Factor de Necrosis Tumoral
CIE Terms
Keywords
Fever, Headache, Antibodies, Encephalitis
Citation
Cabezudo-García P, Vidal Denis M, Ciano-Petersen NL, Irigoyen-Oyarzábal MV, Serrano-Castro PJ. FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) in a patient with Crohn's disease on anti-TNF treatment. Neurologia (Engl Ed). 2022 May;37(4):304-306. English, Spanish